Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-07

AUTHORS

D I Watkins, Z W Chen, A L Hughes, M G Evans, T F Tedder, N L Letvin

ABSTRACT

The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T lymphocytes. The evolutionary relationship of the non-classical and classical MHC class I genes is unclear. Here we present the cloning and sequencing of the MHC class I genes of a New World primate, the cotton-top tamarin (Saguinus oedipus). The expressed MHC class I genes of this species are more closely related to the human non-classical HLA-G gene than they are to genes of the human classical HLA-A, -B, and -C loci. These observations imply that classical and non-classical genes do not necessarily constitute mutually exclusive groups over evolutionary time. More... »

PAGES

60-63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/346060a0

DOI

http://dx.doi.org/10.1038/346060a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032074291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2114550


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