Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-06

AUTHORS

C Thaller, G Eichele

ABSTRACT

There is increasing evidence that retinoic acid is a morphogen involved in vertebrate development. This evidence comes in part from studies of the chick wing bud, in which local application of all-trans-retinoic acid results in a duplication of the digit pattern along the anteroposterior axis. Retinoic acid may be only one of several morphogenetic signalling compounds required for limb pattern formation. To identify novel morphogenetically active compounds, fractionated extracts of whole chick embryos were tested for their ability to induce digit pattern duplications. We describe here the isolation of a new activity present in the limb bud, which we have identified as all-trans-3,4-didehydroretinoic acid. The 3,4-didehydroretinoic acid is generated in situ from retinol through a 3,4-didehydroretinol intermediate. We show that 3,4-didehydroretinoic acid and retinoic acid are equipotent in evoking digit duplications. These findings suggest that there are at least two endogenous retinoids with morphogenetic properties in the chick limb. More... »

PAGES

815-819

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/345815a0

DOI

http://dx.doi.org/10.1038/345815a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027682973

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2359458


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