Presentation of viral antigen controlled by a gene in the major histocompatibility complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

V. Cerundolo, J. Alexander, K. Anderson, C. Lamb, P. Cresswell, A. McMichael, F. Gotch, A. Townsend

ABSTRACT

WE describe a mutant human cell line (LBL 721.174)1,2 that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules2,3,4, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6. More... »

PAGES

449-452

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/345449a0

DOI

http://dx.doi.org/10.1038/345449a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017575516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2342577


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