Genetic organization of a chimpanzee lentivirus related to HIV-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-05

AUTHORS

T Huet, R Cheynier, A Meyerhans, G Roelants, S Wain-Hobson

ABSTRACT

Simian immunodeficiency viruses have been isolated from four species of monkey, the 'captive' macaque and mangabey and the 'feral' African green monkey and mandrill. While none of these viruses is a replica of HIV-1, the macaque and mangabey viruses represent correct genetic models for HIV-2, possessing exactly the same complement of genes. Recently a lentivirus has been identified in two wild chimpanzees (Pan troglodytes troglodytes) in Gabon, west equatorial Africa, and isolated from one of them. This virus is referred to as SIVCPZ. Sera from these animals cross reacted with all the HIV-1 proteins including the envelope glycoproteins. Here, we describe the molecular cloning and sequencing of an infectious proviral clone of SIVCPZ. The overall genetic organization was the same as that of HIV-1, but phylogenetic analysis revealed that the sequence was more divergent than any HIV-1 sequence reported so far. The vpu gene product, found only in the type 1 viruses, was particularly different (64% divergent to HIV-1BRU) suggesting that the SIVCPZ represents a distinct subtype. These findings indicate that there is a larger pool of simian lentiviruses than previously suspected and revives debate as to the origins of HIV-1. More... »

PAGES

356-359

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/345356a0

DOI

http://dx.doi.org/10.1038/345356a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005318283

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2188136


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