Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-04

AUTHORS

Hans-Michael Jantzen, Arie Admon, Stephen P. Bell, Robert Tjian

ABSTRACT

The eukaryotic upstream binding factor (DBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA poly-merase I through cooperative interactions with the species-specific factor, SL1. Isolation of complementary DNA clones and sequence analysis reveals similarities between DNA binding domains of human UBF (hUBF) and high mobility group (HMG) protein 1. Expression, cellular localization and in vitro transcription studies establish that cloned hUBF encodes a nucleolar factor that binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner. More... »

PAGES

830-836

Journal

TITLE

Nature

ISSUE

6269

VOLUME

344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/344830a0

DOI

http://dx.doi.org/10.1038/344830a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029134669

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2330041


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