Molecular components of the B-cell antigen receptor complex of the IgM class View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-02

AUTHORS

J Hombach, T Tsubata, L Leclercq, H Stappert, M Reth

ABSTRACT

The antigen receptors on mature B lymphocytes are membrane-bound immunoglobulins of the IgM and IgD classes whose cross-linking by polyvalent antigens results in B-cell proliferation and differentiation. How these membrane-bound immunoglobulin chains, which lack a cytoplasmic tail, generate a cell activation signal is not at present known. We now show that the IgM molecule is non-covalently associated in the membrane of B cells with two proteins of relative molecular mass 34,000 (Mr 34 K; IgM-alpha) and 39 K (Ig-beta) which form a disulphide-linked heterodimer. Surface expression of IgM seems to require the formation of an appropriate complex between IgM and the heterodimer. A transfection experiment indicates that IgM-alpha is the product of mb-1, a B-cell specific gene encoding a transmembrane protein with sequence homology to proteins of the T-cell antigen receptor-CD3 complex. More... »

PAGES

760-762

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/343760a0

DOI

http://dx.doi.org/10.1038/343760a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021388704

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2304550


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