Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-01

AUTHORS

Shelley Halpain, Jean-Antoine Girault, Paul Greengard

ABSTRACT

IN the caudate-putamen the glutamatergic cortical input and the dopaminergic nigrostriatal input have opposite effects on the firing rate of striatal neurons l–4. Although little is known of the biochemical mechanisms underlying this antagonism, one action of dopamine is to stimulate the cyclic AMP-dependent phosphorylation of DARPP-32 (dopamine and cAMP-regulated phospho-protein, of relative molecular mass 32,000 (32K))5. This phos-phorylation converts DARPP-32 from an inactive molecule into a potent inhibitor of protein phosphatase-1 (ref. 6). Here we show that activation of the NMDA (TV-methyl-D-aspartate) subclass of glutamate receptors reverses the cAMP-stimulated phos-phorylation of DARPP-32 in striatal slices through NMDA-induced dephosphorylation of DARPP-32. Thus, the antagonistic effects of dopamine and glutamate on the excitability of striatal neurons are reflected in antagonistic effects of these neurotransmitters on the state of phosphorylation of DARPP-32. Our results indicate that stimulation of NMDA receptors leads to the activation of a neuronal protein phosphatase, presumably the calcium-dependent phosphatase calcineurin, and show, in an intact cell preparation, that signal transduction in the nervous system can be mediated by protein dephosphorylation. More... »

PAGES

369-372

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/343369a0

DOI

http://dx.doi.org/10.1038/343369a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010822504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2153935


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