Ontology type: schema:ScholarlyArticle
1989-11
AUTHORSK Deres, H Schild, K H Wiesmüller, G Jung, H G Rammensee
ABSTRACTCytotoxic T lymphocytes (CTL) constitute an essential part of the immune response against viral infections. Such CTL recognize peptides derived from viral proteins together with major histocompatibility complex (MHC) class I molecules on the surface of infected cells, and usually require in vivo priming with infectious virus. Here we report that synthetic viral peptides covalently linked to tripalmitoyl-S-glycerylcysteinyl-seryl-serine (P3CSS) can efficiently prime influenza-virus-specific CTL in vivo. These lipopeptides are able to induce the same high-affinity CTL as does the infectious virus. Our data are not only relevant to vaccine development, but also have a bearing on basic immune processes leading to the transition of virgin T cells to activated effector cells in vivo, and to antigen presentation by MHC class I molecules. More... »
PAGES561-564
http://scigraph.springernature.com/pub.10.1038/342561a0
DOIhttp://dx.doi.org/10.1038/342561a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2586628
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