In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-11

AUTHORS

K Deres, H Schild, K H Wiesmüller, G Jung, H G Rammensee

ABSTRACT

Cytotoxic T lymphocytes (CTL) constitute an essential part of the immune response against viral infections. Such CTL recognize peptides derived from viral proteins together with major histocompatibility complex (MHC) class I molecules on the surface of infected cells, and usually require in vivo priming with infectious virus. Here we report that synthetic viral peptides covalently linked to tripalmitoyl-S-glycerylcysteinyl-seryl-serine (P3CSS) can efficiently prime influenza-virus-specific CTL in vivo. These lipopeptides are able to induce the same high-affinity CTL as does the infectious virus. Our data are not only relevant to vaccine development, but also have a bearing on basic immune processes leading to the transition of virgin T cells to activated effector cells in vivo, and to antigen presentation by MHC class I molecules. More... »

PAGES

561-564

Journal

TITLE

Nature

ISSUE

6249

VOLUME

342

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/342561a0

    DOI

    http://dx.doi.org/10.1038/342561a0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2586628


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