The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-11

AUTHORS

C Rayssiguier, D S Thaler, M Radman

ABSTRACT

The requirement for DNA sequence homology in generalized genetic recombination is greatly relaxed in bacterial mutL, mutS and mutH mutants deficient in mismatch repair. In such mutants, intergeneric recombination occurs efficiently between Escherichia coli and Salmonella typhimurium, which are approximately 20% divergent in DNA sequence. This finding has implications for speciation, for regulating recombination between diverged repeated sequences, and for hitherto difficult interspecies hybridizations. More... »

PAGES

396-401

Journal

TITLE

Nature

ISSUE

6248

VOLUME

342

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/342396a0

DOI

http://dx.doi.org/10.1038/342396a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001462115

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2555716


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