Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

J Kaye, M L Hsu, M E Sauron, S C Jameson, N R Gascoigne, S M Hedrick

ABSTRACT

T lymphocytes are predisposed to recognition of foreign protein fragments bound to cell-surface molecules encoded by the major histocompatibility complex (MHC). There is now compelling evidence that this specificity is a consequence of a selection process operating on developing T lymphocytes in the thymus. As a result of this positive selection, thymocytes that express antigen receptors with a threshold affinity for self MHC-encoded glycoproteins preferentially emigrate from the thymus and seed peripheral lymphoid organs. The specificity for both foreign antigen and MHC molecules is imparted by the alpha and beta chains of the T-cell antigen receptor (TCR). Two other T-cell surface proteins, CD4 and CD8, which bind non-polymorphic regions of class II and class I MHC molecules respectively, are also involved in these recognition events and play an integral role in thymic selection. In order to elucidate the developmental pathways of class II MHC-restricted T cells in relation to these essential accessory molecules, we have produced TCR-transgenic mice expressing a receptor specific for a fragment of pigeon cytochrome c and the Ek (class II MHC) molecule. The transgenic TCR is expressed on virtually all T cells in mice expressing Ek. The thymuses of these mice contain an abnormally high percentage of mature CD4+CD8- cells. In addition, the peripheral T-cell population is almost exclusively CD4+, demonstrating that the MHC specificity of the TCR determines the phenotype of T cells during selection in the thymus. More... »

PAGES

746-749

References to SciGraph publications

  • 1988-10. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules in NATURE
  • 1988-10. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens in NATURE
  • 1988-12. Analysis of specificity for antigen, Mls, and allogeneic MHC by transfer of T-cell receptor α- and β-chain genes in NATURE
  • 1988-09. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells in NATURE
  • 1986-03. Transfer of specificity by murine α and β T-cell receptor genes in NATURE
  • 1988-08. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage in NATURE
  • 1987-04. CD4+ murine T cells develop from CD8+ precursors in vivo in NATURE
  • 1987-07. Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor in NATURE
  • 1986-12. Predominant use of a Vα gene segment in mouse T-cell receptors for cytochrome c in NATURE
  • 1988-09. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice in NATURE
  • 1986-05. Correlations between T-cell specificity and the structure of the antigen receptor in NATURE
  • 1977-09. In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells in NATURE
  • 1988-11. Positive and negative selection of an antigen receptor on T cells in transgenic mice in NATURE
  • 1987-01. Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes in NATURE
  • 1988-11. Cell-cell adhesion mediated by CD8 and MHC class I molecules in NATURE
  • 1987-11. Interaction between CD4 and class II MHC molecules mediates cell adhesion in NATURE
  • 1985-09. Binding of immunogenic peptides to Ia histocompatibility molecules in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/341746a0

    DOI

    http://dx.doi.org/10.1038/341746a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026697511

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2571940


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