Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

Duncan McVey, Leonardo Brizuela, Ian Mohr, Daniel R. Marshak, Yasha Gluzman, David Beach

ABSTRACT

Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication. More... »

PAGES

503-507

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/341503a0

DOI

http://dx.doi.org/10.1038/341503a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025572809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2552322


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