Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-10

AUTHORS

S Porcelli, M B Brenner, J L Greenstein, S P Balk, C Terhorst, P A Bleicher

ABSTRACT

Human cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of unknown function expressed on immature thymocytes, epidermal Langerhans cells and a subset of B lymphocytes. Three homologous proteins, CD1a, b and c, have been defined serologically, and the CD1 gene locus on human chromosome 1 contains five potential CD1 genes. Analysis of the predicted amino-acid sequences of CD1 molecules reveals a low but significant level of homology to major histocompatibility complex (MHC) class I and class II molecules, and, like MHC class I molecules, CD1 molecules are associated non-covalently with beta 2-microglobulin. These structural similarities to known antigen-presenting molecules, together with the expression of CD1 on cells capable of antigen presentation, suggest a role for CD1 molecules in antigen recognition by T cells. Here we demonstrate the specific recognition of CD1a by a CD4-CD8- alpha beta T-cell receptor (TCR) expressing cytolytic T lymphocyte (CTL) line and the specific recognition of CD1c by a CD4-CD8- gamma delta TCR CTL line. The interaction of CD1-specific CTLs with CD1+ target cells appeared to involve the CD3-TCR complex, and did not show evidence of MHC restriction. These results suggest that for a subset of T cells, CD1 molecules serve a function analogous to that of MHC class I and II molecules. More... »

PAGES

447-450

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/341447a0

DOI

http://dx.doi.org/10.1038/341447a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015301176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2477705


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