Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-05

AUTHORS

Marshall Plaut, Jacalyn H. Pierce, Cynthia J. Watson, Joan Hanley-Hyde, Richard P. Nordan, William E. Paul

ABSTRACT

THE cross-linkage of high affinity Fcε receptors (FcεRI) on mast cells and basophils is central to the induction of allergic inflammatory responses. As a result of such cross-linkage, mast cells secrete a variety of preformed biologically active substances, such as histamine, and newly synthesized arachidonic acid metabolites1. Here we show that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells)2. These factors include interleukin-3 (a mast cell growth factor)s interleukin-4 (an IgE 'switch factor'), interleukin-5 (an eosinophil differentiation factor) and interleukin-6 (a factor controlling immunoglobulin secretion). The production of these polypeptide factors by mast cells may have great importance in the induction of allergic and anti-parasite inflammatory responses. More... »

PAGES

64-67

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/339064a0

DOI

http://dx.doi.org/10.1038/339064a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044020761

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2469965


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