G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-02

AUTHORS

D Kim, D L Lewis, L Graziadei, E J Neer, D Bar-Sagi, D E Clapham

ABSTRACT

Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and beta gamma-subunits applied to the intracellular surface of inside-out patches of membrane. beta gamma has been shown to activate the membrane-bound enzyme phospholipase A2 in retinal rods. Arachidonic acid, which is produced from the action of phospholipase A2 on phospholipids, is metabolized to compounds which may act as second messengers regulating ion channels in Aplysia. Muscarinic receptor activation leads to the generation of arachidonic acid in some cell lines. We therefore tested the hypothesis that beta gamma activates IK.ACh by stimulation of phospholipase A2. When patches were first incubated with antibody that blocks phospholipase A2 activity, or with the lipoxygenase inhibitor, nordihydroguaiaretic acid, beta gamma failed to activate IK.ACh. Arachidonic acid and several of its metabolites derived from the 5-lipoxygenase pathway, activated the channel. Blockade of the cyclooxygenase pathway did not inhibit arachidonic acid-induced channel activation. We conclude that the beta gamma-subunit of G-proteins activates IK.ACh by stimulating the production of lipoxygenase-derived second messengers. More... »

PAGES

557

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/337557a0

DOI

http://dx.doi.org/10.1038/337557a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035646914

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2492640


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arachidonic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arachidonic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding, Competitive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukotrienes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipases A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipases A2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Potassium Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Muscarinic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "D", 
        "id": "sg:person.01302476157.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302476157.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lewis", 
        "givenName": "D L", 
        "id": "sg:person.01212664237.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212664237.78"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Graziadei", 
        "givenName": "L", 
        "id": "sg:person.0633021504.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633021504.60"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Neer", 
        "givenName": "E J", 
        "id": "sg:person.0623161530.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623161530.56"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bar-Sagi", 
        "givenName": "D", 
        "id": "sg:person.0706716577.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706716577.76"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Clapham", 
        "givenName": "D E", 
        "id": "sg:person.0672201126.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672201126.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/328038a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003772724", 
          "https://doi.org/10.1038/328038a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/328038a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003772724", 
          "https://doi.org/10.1038/328038a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.56.070187.003151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008989779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/337555a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016380921", 
          "https://doi.org/10.1038/337555a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317536a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020211632", 
          "https://doi.org/10.1038/317536a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2040003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027493290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2040003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027493290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.106.5.1649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031362825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/333129a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032720750", 
          "https://doi.org/10.1038/333129a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/317538a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032730182", 
          "https://doi.org/10.1038/317538a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.50.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036364185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325321a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042146376", 
          "https://doi.org/10.1038/325321a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325321a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042146376", 
          "https://doi.org/10.1038/325321a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2436299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062537602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2454511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2457252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079545777", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079922899", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1989-02", 
    "datePublishedReg": "1989-02-01", 
    "description": "Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and beta gamma-subunits applied to the intracellular surface of inside-out patches of membrane. beta gamma has been shown to activate the membrane-bound enzyme phospholipase A2 in retinal rods. Arachidonic acid, which is produced from the action of phospholipase A2 on phospholipids, is metabolized to compounds which may act as second messengers regulating ion channels in Aplysia. Muscarinic receptor activation leads to the generation of arachidonic acid in some cell lines. We therefore tested the hypothesis that beta gamma activates IK.ACh by stimulation of phospholipase A2. When patches were first incubated with antibody that blocks phospholipase A2 activity, or with the lipoxygenase inhibitor, nordihydroguaiaretic acid, beta gamma failed to activate IK.ACh. Arachidonic acid and several of its metabolites derived from the 5-lipoxygenase pathway, activated the channel. Blockade of the cyclooxygenase pathway did not inhibit arachidonic acid-induced channel activation. We conclude that the beta gamma-subunit of G-proteins activates IK.ACh by stimulating the production of lipoxygenase-derived second messengers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/337557a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6207", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "337"
      }
    ], 
    "name": "G-protein \u03b2\u03b3-subunits activate the cardiac muscarinic K+-channel via phospholipase A2", 
    "pagination": "557", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a9cf45d2a69c1c85a735a585aaf7e7afeea336e857e174ba1bd1aa0262c4c0b1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2492640"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/337557a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035646914"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/337557a0", 
      "https://app.dimensions.ai/details/publication/pub.1035646914"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/337557a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/337557a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/337557a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/337557a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/337557a0'


 

This table displays all metadata directly associated to this object as RDF triples.

208 TRIPLES      21 PREDICATES      59 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/337557a0 schema:about N064cf3ce3b6f48a09e6c47a68ae66823
2 N2d47be25974044eb8f855bc9a0caabaf
3 N2ee727e3a5434811969239b7216189de
4 N5f353fe6a6874a94844e901adf6c624b
5 N7a23c5882f2b4dedb7f7ef45e8f61156
6 N8358b09d63874aec88b0a01fd0e4e32e
7 N84ab050ed7584fbe8151b2e5705dec07
8 N944f1a68ab1c4a14a32c96fe5343cf2d
9 Na12b8ae672834b4392c9fab99e5990b2
10 Na30c30ca09dc46188984fe8b066287d5
11 Nbfe84d5c23e948adad9550cedef0b5ab
12 Nca86cdd5060f40a9847b85e58ab045dd
13 Ne134beef69054c2089a6d20b3d14ee4f
14 Ne3cf27fea36e45ccb87c99a4759a0e1d
15 Nfc2e0acf9c0e4542aeb1afd4fe4fe47d
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N84fbf9eb02ed49ce874a9ae41b80dd1d
19 schema:citation sg:pub.10.1038/317536a0
20 sg:pub.10.1038/317538a0
21 sg:pub.10.1038/325321a0
22 sg:pub.10.1038/328038a0
23 sg:pub.10.1038/333129a0
24 sg:pub.10.1038/337555a0
25 https://app.dimensions.ai/details/publication/pub.1079545777
26 https://app.dimensions.ai/details/publication/pub.1079922899
27 https://doi.org/10.1042/bj2040003
28 https://doi.org/10.1083/jcb.106.5.1649
29 https://doi.org/10.1126/science.2436299
30 https://doi.org/10.1126/science.2454511
31 https://doi.org/10.1126/science.2457252
32 https://doi.org/10.1146/annurev.bi.56.070187.003151
33 https://doi.org/10.1161/01.res.50.1.101
34 schema:datePublished 1989-02
35 schema:datePublishedReg 1989-02-01
36 schema:description Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and beta gamma-subunits applied to the intracellular surface of inside-out patches of membrane. beta gamma has been shown to activate the membrane-bound enzyme phospholipase A2 in retinal rods. Arachidonic acid, which is produced from the action of phospholipase A2 on phospholipids, is metabolized to compounds which may act as second messengers regulating ion channels in Aplysia. Muscarinic receptor activation leads to the generation of arachidonic acid in some cell lines. We therefore tested the hypothesis that beta gamma activates IK.ACh by stimulation of phospholipase A2. When patches were first incubated with antibody that blocks phospholipase A2 activity, or with the lipoxygenase inhibitor, nordihydroguaiaretic acid, beta gamma failed to activate IK.ACh. Arachidonic acid and several of its metabolites derived from the 5-lipoxygenase pathway, activated the channel. Blockade of the cyclooxygenase pathway did not inhibit arachidonic acid-induced channel activation. We conclude that the beta gamma-subunit of G-proteins activates IK.ACh by stimulating the production of lipoxygenase-derived second messengers.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N76c35105b7b04cb18e20e90a6ffe641d
41 Nc39994ccef6c4480afec914ef92ed698
42 sg:journal.1018957
43 schema:name G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2
44 schema:pagination 557
45 schema:productId N1114bf6caf6b4874a5b7abea3e02b70f
46 N787827d56ba742b0b07e00178e637aa2
47 N84b056f0b08a4c37bee118140d5043d1
48 Ndc4ce635f28d47ecb2450efd831be37c
49 Nff351482f0aa4739aafbfa198fcabe89
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035646914
51 https://doi.org/10.1038/337557a0
52 schema:sdDatePublished 2019-04-10T23:12
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher Nc998c38354f340cca50c342970f6510a
55 schema:url https://www.nature.com/articles/337557a0
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N064cf3ce3b6f48a09e6c47a68ae66823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Phosphatidylinositols
61 rdf:type schema:DefinedTerm
62 N1114bf6caf6b4874a5b7abea3e02b70f schema:name doi
63 schema:value 10.1038/337557a0
64 rdf:type schema:PropertyValue
65 N2d47be25974044eb8f855bc9a0caabaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Leukotrienes
67 rdf:type schema:DefinedTerm
68 N2ee727e3a5434811969239b7216189de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Arachidonic Acid
70 rdf:type schema:DefinedTerm
71 N4e16132fd9764a17a4b3a0dd3f761703 rdf:first sg:person.0706716577.76
72 rdf:rest Nda0e566f899b4d1c9e691530a096121b
73 N5f353fe6a6874a94844e901adf6c624b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Binding, Competitive
75 rdf:type schema:DefinedTerm
76 N76c35105b7b04cb18e20e90a6ffe641d schema:issueNumber 6207
77 rdf:type schema:PublicationIssue
78 N787827d56ba742b0b07e00178e637aa2 schema:name dimensions_id
79 schema:value pub.1035646914
80 rdf:type schema:PropertyValue
81 N79da81b7b7614a5ab862c96b1730f200 rdf:first sg:person.01212664237.78
82 rdf:rest Ne6f99c1bd41142a88ffeb7e24948bb83
83 N7a23c5882f2b4dedb7f7ef45e8f61156 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Receptors, Muscarinic
85 rdf:type schema:DefinedTerm
86 N8358b09d63874aec88b0a01fd0e4e32e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Potassium Channels
88 rdf:type schema:DefinedTerm
89 N84ab050ed7584fbe8151b2e5705dec07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Arachidonic Acids
91 rdf:type schema:DefinedTerm
92 N84b056f0b08a4c37bee118140d5043d1 schema:name pubmed_id
93 schema:value 2492640
94 rdf:type schema:PropertyValue
95 N84fbf9eb02ed49ce874a9ae41b80dd1d rdf:first sg:person.01302476157.11
96 rdf:rest N79da81b7b7614a5ab862c96b1730f200
97 N944f1a68ab1c4a14a32c96fe5343cf2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Nerve Tissue Proteins
99 rdf:type schema:DefinedTerm
100 Na12b8ae672834b4392c9fab99e5990b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Rats
102 rdf:type schema:DefinedTerm
103 Na30c30ca09dc46188984fe8b066287d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Enzyme Activation
105 rdf:type schema:DefinedTerm
106 Nbb931b273c274f3ea33389d053ce48ae rdf:first sg:person.0623161530.56
107 rdf:rest N4e16132fd9764a17a4b3a0dd3f761703
108 Nbfe84d5c23e948adad9550cedef0b5ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Myocardium
110 rdf:type schema:DefinedTerm
111 Nc39994ccef6c4480afec914ef92ed698 schema:volumeNumber 337
112 rdf:type schema:PublicationVolume
113 Nc998c38354f340cca50c342970f6510a schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Nca86cdd5060f40a9847b85e58ab045dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Phospholipases A
117 rdf:type schema:DefinedTerm
118 Nda0e566f899b4d1c9e691530a096121b rdf:first sg:person.0672201126.59
119 rdf:rest rdf:nil
120 Ndc4ce635f28d47ecb2450efd831be37c schema:name readcube_id
121 schema:value a9cf45d2a69c1c85a735a585aaf7e7afeea336e857e174ba1bd1aa0262c4c0b1
122 rdf:type schema:PropertyValue
123 Ne134beef69054c2089a6d20b3d14ee4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Phospholipases A2
125 rdf:type schema:DefinedTerm
126 Ne3cf27fea36e45ccb87c99a4759a0e1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Phospholipases
128 rdf:type schema:DefinedTerm
129 Ne6f99c1bd41142a88ffeb7e24948bb83 rdf:first sg:person.0633021504.60
130 rdf:rest Nbb931b273c274f3ea33389d053ce48ae
131 Nfc2e0acf9c0e4542aeb1afd4fe4fe47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Animals
133 rdf:type schema:DefinedTerm
134 Nff351482f0aa4739aafbfa198fcabe89 schema:name nlm_unique_id
135 schema:value 0410462
136 rdf:type schema:PropertyValue
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biochemistry and Cell Biology
142 rdf:type schema:DefinedTerm
143 sg:journal.1018957 schema:issn 0090-0028
144 1476-4687
145 schema:name Nature
146 rdf:type schema:Periodical
147 sg:person.01212664237.78 schema:familyName Lewis
148 schema:givenName D L
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212664237.78
150 rdf:type schema:Person
151 sg:person.01302476157.11 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
152 schema:familyName Kim
153 schema:givenName D
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302476157.11
155 rdf:type schema:Person
156 sg:person.0623161530.56 schema:familyName Neer
157 schema:givenName E J
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623161530.56
159 rdf:type schema:Person
160 sg:person.0633021504.60 schema:familyName Graziadei
161 schema:givenName L
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633021504.60
163 rdf:type schema:Person
164 sg:person.0672201126.59 schema:familyName Clapham
165 schema:givenName D E
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672201126.59
167 rdf:type schema:Person
168 sg:person.0706716577.76 schema:familyName Bar-Sagi
169 schema:givenName D
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706716577.76
171 rdf:type schema:Person
172 sg:pub.10.1038/317536a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020211632
173 https://doi.org/10.1038/317536a0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/317538a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032730182
176 https://doi.org/10.1038/317538a0
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/325321a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146376
179 https://doi.org/10.1038/325321a0
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/328038a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003772724
182 https://doi.org/10.1038/328038a0
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/333129a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032720750
185 https://doi.org/10.1038/333129a0
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/337555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016380921
188 https://doi.org/10.1038/337555a0
189 rdf:type schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1079545777 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1079922899 schema:CreativeWork
192 https://doi.org/10.1042/bj2040003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027493290
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1083/jcb.106.5.1649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031362825
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1126/science.2436299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062537602
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1126/science.2454511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538412
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1126/science.2457252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538425
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1146/annurev.bi.56.070187.003151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008989779
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1161/01.res.50.1.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036364185
205 rdf:type schema:CreativeWork
206 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
207 schema:name Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905.
208 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...