Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-01

AUTHORS

Lung-Ji Chang, Peter Pryciak, Don Ganem, Harold E. Varmus

ABSTRACT

Retroviruses and many other types of genetic elements replicate by reverse transcription of RNA (for reviews, see refs 1 and 2). Although structurally and biologically very diverse, such elements carry conserved polymerase genes (pol) that encode proteins required for reverse transcription3. In most cases, the pol gene is preceded by an overlapping gene encoding one or more nucleocapsid proteins4, in a different reading frame. Because both coding regions are represented in a single mRNA, the question arises of how the reverse transcriptase in the alternative reading frame is expressed. In retroviruses and retrotransposons it is expressed as a nucleocapsid-polymerase fusion protein by ribosomal frameshift-ing during translation of the overlapping region5–8. We have examined the mechanism of polymerase biosynthesis in another family of animal viruses that use reverse transcription, the hepatitis B viruses. Genetic and biochemical studies reveal that these viruses do not use ribosomal frameshifting to generate this enzyme, but instead direct translation initiation at an internal initiation (AUG) codon in the polymerase gene. More... »

PAGES

364-368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/337364a0

DOI

http://dx.doi.org/10.1038/337364a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035604737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2463489


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