Ontology type: schema:ScholarlyArticle
1989-01
AUTHORST A Haystead, A T Sim, D Carling, R C Honnor, Y Tsukitani, P Cohen, D G Hardie
ABSTRACTOkadaic acid is a polyether derivative of 38-carbon fatty acid, and is implicated as the causative agent of diarrhetic shellfish poisoning. It is a potent tumour promoter that is not an activator of protein kinase C, but is a powerful inhibitor of protein phosphatases-1 and -2A (PP1 and PP2A) in vitro. We report here that okadaic acid rapidly stimulates protein phosphorylation in intact cells, and behaves like a specific protein phosphatase inhibitor in a variety of metabolic processes. Our results indicate that PP1 and PP2A are the dominant protein phosphatases acting on a wide range of phosphoproteins in vivo. We also find that okadaic acid mimics the effect of insulin on glucose transport in adipocytes, which suggests that this process is stimulated by a serine/threonine phosphorylation event. More... »
PAGES78-81
http://scigraph.springernature.com/pub.10.1038/337078a0
DOIhttp://dx.doi.org/10.1038/337078a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/2562908
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