Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

William C. Sha, Christopher A. Nelson, Rodney D. Newberry, David M. Kranzt, John H. Russell, Dennis Y. Loh

ABSTRACT

The major problem in the study of T-cell development is that of tracking thymocytes of a given specificity. Recent studies1–4 have exploited natural correlations between the expression of a particular Vβ gene segment and T-cell receptor (TCR) specificity. We and others (refs 5,6 and M. Davis, personal communication) have taken an alternative approach. We have generated transgenic mice expressing the αβ antigen receptor from the cytotoxic T-lymphocyte clone 2C (ref. 7). In transgenic mice of the same haplotype as the 2C clone, the 2C TCR was expressed on 20–95% of peripheral T cells. Very few of these T cells carried the CD4 antigen; the vast majority were CD4–CD8+ and were able to lyse targets with the same specificity as the original 2C clone. These results indicate that the αβ heterodimer transfers specificity to recipient cells as expected from earlier studies8–11, and that receptor specificity in T-cell repertoire selection is determined by both αβ heterodimer and CD4 or CD8 accessory molecules. More... »

PAGES

271-274

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/335271a0

DOI

http://dx.doi.org/10.1038/335271a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048531773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3261843


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Antigen, T-Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Cytotoxic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sha", 
        "givenName": "William C.", 
        "id": "sg:person.01214765313.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214765313.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelson", 
        "givenName": "Christopher A.", 
        "id": "sg:person.013701330707.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701330707.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newberry", 
        "givenName": "Rodney D.", 
        "id": "sg:person.01067601365.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067601365.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, University of Illinois, 61801, Urbana, Illinois, USA", 
          "id": "http://www.grid.ac/institutes/grid.35403.31", 
          "name": [
            "Department of Biochemistry, University of Illinois, 61801, Urbana, Illinois, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kranzt", 
        "givenName": "David M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pharmacology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russell", 
        "givenName": "John H.", 
        "id": "sg:person.011257715452.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011257715452.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loh", 
        "givenName": "Dennis Y.", 
        "id": "sg:person.01351755114.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351755114.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/333742a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018116885", 
          "https://doi.org/10.1038/333742a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312036a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041577472", 
          "https://doi.org/10.1038/312036a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326798a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009831509", 
          "https://doi.org/10.1038/326798a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/332040a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005850323", 
          "https://doi.org/10.1038/332040a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325125a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029618957", 
          "https://doi.org/10.1038/325125a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316832a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018970869", 
          "https://doi.org/10.1038/316832a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/314098a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013544094", 
          "https://doi.org/10.1038/314098a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/319028a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011022507", 
          "https://doi.org/10.1038/319028a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/332035a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028163401", 
          "https://doi.org/10.1038/332035a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/320232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028015241", 
          "https://doi.org/10.1038/320232a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988-09", 
    "datePublishedReg": "1988-09-01", 
    "description": "The major problem in the study of T-cell development is that of tracking thymocytes of a given specificity. Recent studies1\u20134 have exploited natural correlations between the expression of a particular V\u03b2 gene segment and T-cell receptor (TCR) specificity. We and others (refs 5,6 and M. Davis, personal communication) have taken an alternative approach. We have generated transgenic mice expressing the \u03b1\u03b2 antigen receptor from the cytotoxic T-lymphocyte clone 2C (ref. 7). In transgenic mice of the same haplotype as the 2C clone, the 2C TCR was expressed on 20\u201395% of peripheral T cells. Very few of these T cells carried the CD4 antigen; the vast majority were CD4\u2013CD8+ and were able to lyse targets with the same specificity as the original 2C clone. These results indicate that the \u03b1\u03b2 heterodimer transfers specificity to recipient cells as expected from earlier studies8\u201311, and that receptor specificity in T-cell repertoire selection is determined by both \u03b1\u03b2 heterodimer and CD4 or CD8 accessory molecules.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/335271a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2683699", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6187", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "335"
      }
    ], 
    "keywords": [
      "transgenic mice", 
      "T cells", 
      "CD8-bearing T lymphocytes", 
      "antigen receptor", 
      "T cell repertoire selection", 
      "T cell receptor specificity", 
      "\u03b1\u03b2 antigen receptor", 
      "CD8 accessory molecules", 
      "receptor specificity", 
      "peripheral T cells", 
      "T cell development", 
      "CD4-CD8", 
      "CD4 antigen", 
      "T lymphocytes", 
      "accessory molecules", 
      "clone 2C", 
      "repertoire selection", 
      "mice", 
      "selective expression", 
      "V\u03b2 gene segments", 
      "receptors", 
      "same specificity", 
      "specificity", 
      "cells", 
      "gene segments", 
      "vast majority", 
      "CD4", 
      "lymphocytes", 
      "expression", 
      "same haplotype", 
      "antigen", 
      "thymocytes", 
      "TCR", 
      "clones", 
      "\u03b1\u03b2 heterodimer", 
      "major problem", 
      "majority", 
      "target", 
      "haplotypes", 
      "study", 
      "correlation", 
      "heterodimers", 
      "segments", 
      "alternative approach", 
      "development", 
      "results", 
      "molecules", 
      "selection", 
      "transfer specificity", 
      "approach", 
      "problem", 
      "natural correlation"
    ], 
    "name": "Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice", 
    "pagination": "271-274", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048531773"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/335271a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3261843"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/335271a0", 
      "https://app.dimensions.ai/details/publication/pub.1048531773"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T21:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_192.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/335271a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/335271a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/335271a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/335271a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/335271a0'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      22 PREDICATES      97 URIs      79 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/335271a0 schema:about N4883e8bf10a04a29b01fb816862b5281
2 N8fe1cde0f29a4961b04669a0c2dc688d
3 N921f0077203945e99c7c2fd751f9eb54
4 N92bc6ab4c55f401b9d19fc6fc7d80c33
5 N9f882a005d944a3ca63ddfccafea1e1f
6 Naedb73a75a774e3b8e29668af3ee2b36
7 Nb0216a4af875494cb8191091cf51f955
8 Nd4d1bec891dc41ce9b2d11f98c7d139b
9 anzsrc-for:11
10 anzsrc-for:1107
11 schema:author N36f0aba98cf54b1eb593b10685112b52
12 schema:citation sg:pub.10.1038/312036a0
13 sg:pub.10.1038/314098a0
14 sg:pub.10.1038/316832a0
15 sg:pub.10.1038/319028a0
16 sg:pub.10.1038/320232a0
17 sg:pub.10.1038/325125a0
18 sg:pub.10.1038/326798a0
19 sg:pub.10.1038/332035a0
20 sg:pub.10.1038/332040a0
21 sg:pub.10.1038/333742a0
22 schema:datePublished 1988-09
23 schema:datePublishedReg 1988-09-01
24 schema:description The major problem in the study of T-cell development is that of tracking thymocytes of a given specificity. Recent studies1–4 have exploited natural correlations between the expression of a particular Vβ gene segment and T-cell receptor (TCR) specificity. We and others (refs 5,6 and M. Davis, personal communication) have taken an alternative approach. We have generated transgenic mice expressing the αβ antigen receptor from the cytotoxic T-lymphocyte clone 2C (ref. 7). In transgenic mice of the same haplotype as the 2C clone, the 2C TCR was expressed on 20–95% of peripheral T cells. Very few of these T cells carried the CD4 antigen; the vast majority were CD4–CD8+ and were able to lyse targets with the same specificity as the original 2C clone. These results indicate that the αβ heterodimer transfers specificity to recipient cells as expected from earlier studies8–11, and that receptor specificity in T-cell repertoire selection is determined by both αβ heterodimer and CD4 or CD8 accessory molecules.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N838713ef285a49daa8872f5f3e388330
29 Na81aa4a4d3d94fe284fd1a03c557a752
30 sg:journal.1018957
31 schema:keywords CD4
32 CD4 antigen
33 CD4-CD8
34 CD8 accessory molecules
35 CD8-bearing T lymphocytes
36 T cell development
37 T cell receptor specificity
38 T cell repertoire selection
39 T cells
40 T lymphocytes
41 TCR
42 Vβ gene segments
43 accessory molecules
44 alternative approach
45 antigen
46 antigen receptor
47 approach
48 cells
49 clone 2C
50 clones
51 correlation
52 development
53 expression
54 gene segments
55 haplotypes
56 heterodimers
57 lymphocytes
58 major problem
59 majority
60 mice
61 molecules
62 natural correlation
63 peripheral T cells
64 problem
65 receptor specificity
66 receptors
67 repertoire selection
68 results
69 same haplotype
70 same specificity
71 segments
72 selection
73 selective expression
74 specificity
75 study
76 target
77 thymocytes
78 transfer specificity
79 transgenic mice
80 vast majority
81 αβ antigen receptor
82 αβ heterodimer
83 schema:name Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
84 schema:pagination 271-274
85 schema:productId N1f4558aa7215435cac9220022c451a25
86 N3e80ec94a532469cacc822ea9d37a17f
87 Nebe860f1c1964df3a61a1ef2e25a65a6
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048531773
89 https://doi.org/10.1038/335271a0
90 schema:sdDatePublished 2022-06-01T21:59
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N79d7b03b79a4424c899d58339788f658
93 schema:url https://doi.org/10.1038/335271a0
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0d5d873050f641e4868a9271f0a9e335 rdf:first sg:person.01067601365.29
98 rdf:rest Nd7aade0362a9483fa341d3528485859b
99 N1f4558aa7215435cac9220022c451a25 schema:name dimensions_id
100 schema:value pub.1048531773
101 rdf:type schema:PropertyValue
102 N245bacd55fcc48b590fa28ebd2b0c457 rdf:first sg:person.01351755114.97
103 rdf:rest rdf:nil
104 N36f0aba98cf54b1eb593b10685112b52 rdf:first sg:person.01214765313.78
105 rdf:rest N6b4de1798a6548c99a1b625763d9e167
106 N3e80ec94a532469cacc822ea9d37a17f schema:name doi
107 schema:value 10.1038/335271a0
108 rdf:type schema:PropertyValue
109 N4883e8bf10a04a29b01fb816862b5281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Receptors, Antigen, T-Cell
111 rdf:type schema:DefinedTerm
112 N67e2ee4b1aa448ccac5fc25d46eba15e schema:affiliation grid-institutes:grid.35403.31
113 schema:familyName Kranzt
114 schema:givenName David M.
115 rdf:type schema:Person
116 N6b4de1798a6548c99a1b625763d9e167 rdf:first sg:person.013701330707.52
117 rdf:rest N0d5d873050f641e4868a9271f0a9e335
118 N79d7b03b79a4424c899d58339788f658 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N838713ef285a49daa8872f5f3e388330 schema:issueNumber 6187
121 rdf:type schema:PublicationIssue
122 N8fe1cde0f29a4961b04669a0c2dc688d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Thymus Gland
124 rdf:type schema:DefinedTerm
125 N921f0077203945e99c7c2fd751f9eb54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Female
127 rdf:type schema:DefinedTerm
128 N92bc6ab4c55f401b9d19fc6fc7d80c33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name T-Lymphocytes, Cytotoxic
130 rdf:type schema:DefinedTerm
131 N9f882a005d944a3ca63ddfccafea1e1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice, Transgenic
133 rdf:type schema:DefinedTerm
134 Na81aa4a4d3d94fe284fd1a03c557a752 schema:volumeNumber 335
135 rdf:type schema:PublicationVolume
136 Naedb73a75a774e3b8e29668af3ee2b36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Antigens, Differentiation
138 rdf:type schema:DefinedTerm
139 Nb0216a4af875494cb8191091cf51f955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 Nd4d1bec891dc41ce9b2d11f98c7d139b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mice
144 rdf:type schema:DefinedTerm
145 Nd7aade0362a9483fa341d3528485859b rdf:first N67e2ee4b1aa448ccac5fc25d46eba15e
146 rdf:rest Nda116aa8a2ec4165b4f0105b00aa0b4b
147 Nda116aa8a2ec4165b4f0105b00aa0b4b rdf:first sg:person.011257715452.00
148 rdf:rest N245bacd55fcc48b590fa28ebd2b0c457
149 Nebe860f1c1964df3a61a1ef2e25a65a6 schema:name pubmed_id
150 schema:value 3261843
151 rdf:type schema:PropertyValue
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
156 schema:name Immunology
157 rdf:type schema:DefinedTerm
158 sg:grant.2683699 http://pending.schema.org/fundedItem sg:pub.10.1038/335271a0
159 rdf:type schema:MonetaryGrant
160 sg:journal.1018957 schema:issn 0028-0836
161 1476-4687
162 schema:name Nature
163 schema:publisher Springer Nature
164 rdf:type schema:Periodical
165 sg:person.01067601365.29 schema:affiliation grid-institutes:grid.4367.6
166 schema:familyName Newberry
167 schema:givenName Rodney D.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067601365.29
169 rdf:type schema:Person
170 sg:person.011257715452.00 schema:affiliation grid-institutes:grid.4367.6
171 schema:familyName Russell
172 schema:givenName John H.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011257715452.00
174 rdf:type schema:Person
175 sg:person.01214765313.78 schema:affiliation grid-institutes:grid.4367.6
176 schema:familyName Sha
177 schema:givenName William C.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214765313.78
179 rdf:type schema:Person
180 sg:person.01351755114.97 schema:affiliation grid-institutes:grid.4367.6
181 schema:familyName Loh
182 schema:givenName Dennis Y.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351755114.97
184 rdf:type schema:Person
185 sg:person.013701330707.52 schema:affiliation grid-institutes:grid.4367.6
186 schema:familyName Nelson
187 schema:givenName Christopher A.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013701330707.52
189 rdf:type schema:Person
190 sg:pub.10.1038/312036a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041577472
191 https://doi.org/10.1038/312036a0
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/314098a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013544094
194 https://doi.org/10.1038/314098a0
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/316832a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018970869
197 https://doi.org/10.1038/316832a0
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/319028a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011022507
200 https://doi.org/10.1038/319028a0
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/320232a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028015241
203 https://doi.org/10.1038/320232a0
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/325125a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029618957
206 https://doi.org/10.1038/325125a0
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/326798a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009831509
209 https://doi.org/10.1038/326798a0
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/332035a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028163401
212 https://doi.org/10.1038/332035a0
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/332040a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005850323
215 https://doi.org/10.1038/332040a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/333742a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018116885
218 https://doi.org/10.1038/333742a0
219 rdf:type schema:CreativeWork
220 grid-institutes:grid.35403.31 schema:alternateName Department of Biochemistry, University of Illinois, 61801, Urbana, Illinois, USA
221 schema:name Department of Biochemistry, University of Illinois, 61801, Urbana, Illinois, USA
222 rdf:type schema:Organization
223 grid-institutes:grid.4367.6 schema:alternateName Department of Pharmacology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA
224 Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA
225 schema:name Department of Pharmacology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA
226 Departments of Medicine, Genetics, Microbiology, and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 63110, St Louis, Missouri, USA
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...