HLA-A and B polymorphisms predate the divergence of humans and chimpanzees View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

D A Lawlor, F E Ward, P D Ennis, A P Jackson, P Parham

ABSTRACT

Major histocompatibility complex (MHC) glycoproteins bind processed fragments of proteins and present them to the receptors of T lymphocytes. The extraordinary polymorphism of class I MHC molecules in man (HLA-A, B and C) and mouse (H-2 K, D and L) poses many questions concerning their diversification and evolution. Comparison of allelic sequences within a species suggests diversity is generated by the assortment of point mutations into varied combinations by mechanisms of recombination and gene conversion. We have now compared class I MHC alleles in two closely related species: humans (Homo sapiens) and chimpanzees (Pan troglodytes). Chimpanzee homologues of HLA-A, HLA-B and a non-classical gene have been identified. No features distinguishing human and chimpanzee alleles could be found. Individual HLA-A or B alleles are more closely related to individual chimpanzee alleles than to other HLA-A or B alleles. These results show that a considerable proportion of contemporary HLA-A and B polymorphism existed before divergence of the chimpanzee and human lines. The stability of the polymorphism indicates that hyper-mutational mechanisms are not necessary to account for HLA-A, B and C diversity. More... »

PAGES

268

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/335268a0

DOI

http://dx.doi.org/10.1038/335268a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013817676

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3412487


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