Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

Hung Sia Teh, Pawel Kisielow, Bernadette Scott, Hiroyuki Kishi, Yasushi Uematsu, Horst Blüthmann, Harald von Boehmer

ABSTRACT

T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H–2Db-restricted CD4–8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4+8– or CD4–8+ mature T cells. More... »

PAGES

229-233

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/335229a0

DOI

http://dx.doi.org/10.1038/335229a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050728712

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2970593


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