Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

A L Hughes, M Nei

ABSTRACT

The major histocompatibility complex (MHC) loci are known to be highly polymorphic in humans, mice and certain other mammals, with heterozygosity as high as 80-90% (ref. 1). Four different hypotheses have been proposed to explain this high degree of polymorphism: (1) a high mutation rate, (2) gene conversion or interlocus genetic exchange, (3) over dominant selection and (4) frequency-dependent selection. In an attempt to establish which of these hypotheses is correct, we examined the pattern of nucleotide substitution between polymorphic alleles in the region of the antigen recognition site (ARS) and other regions of human and mouse class I MHC genes. The results indicate that in ARS the rate of nonsynonymous (amino acid altering) substitution is significantly higher than that of synonymous substitution in both humans and mice, whereas in other regions the reverse is true. This observation, together with a theoretical study and other considerations, supports the hypothesis of overdominant selection (heterozygote advantage). More... »

PAGES

167-170

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/335167a0

DOI

http://dx.doi.org/10.1038/335167a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035888295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3412472


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