Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-09

AUTHORS

A L Hughes, M Nei

ABSTRACT

The major histocompatibility complex (MHC) loci are known to be highly polymorphic in humans, mice and certain other mammals, with heterozygosity as high as 80-90% (ref. 1). Four different hypotheses have been proposed to explain this high degree of polymorphism: (1) a high mutation rate, (2) gene conversion or interlocus genetic exchange, (3) over dominant selection and (4) frequency-dependent selection. In an attempt to establish which of these hypotheses is correct, we examined the pattern of nucleotide substitution between polymorphic alleles in the region of the antigen recognition site (ARS) and other regions of human and mouse class I MHC genes. The results indicate that in ARS the rate of nonsynonymous (amino acid altering) substitution is significantly higher than that of synonymous substitution in both humans and mice, whereas in other regions the reverse is true. This observation, together with a theoretical study and other considerations, supports the hypothesis of overdominant selection (heterozygote advantage). More... »

PAGES

167-170

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/335167a0

DOI

http://dx.doi.org/10.1038/335167a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035888295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3412472


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, MHC Class I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Selection, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at Houston", 
          "id": "https://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "A L", 
        "id": "sg:person.015075726302.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015075726302.00"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Nei", 
        "givenName": "M", 
        "id": "sg:person.01365207531.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365207531.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/211999a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000978459", 
          "https://doi.org/10.1038/211999a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/12.24.9473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003635419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00430802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004574038", 
          "https://doi.org/10.1007/bf00430802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010030284", 
          "https://doi.org/10.1007/bf00404424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010030284", 
          "https://doi.org/10.1007/bf00404424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/332651a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013515235", 
          "https://doi.org/10.1038/332651a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00430931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018370195", 
          "https://doi.org/10.1007/bf00430931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60229-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021864790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/256050a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023608866", 
          "https://doi.org/10.1038/256050a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/256050a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023608866", 
          "https://doi.org/10.1038/256050a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024286205", 
          "https://doi.org/10.1007/bf00404694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00404694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024286205", 
          "https://doi.org/10.1007/bf00404694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198301000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024759661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198301000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024759661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329506a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027347307", 
          "https://doi.org/10.1038/329506a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00376123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028838770", 
          "https://doi.org/10.1007/bf00376123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/237139a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029056419", 
          "https://doi.org/10.1038/237139a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326096a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040653168", 
          "https://doi.org/10.1038/326096a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/306792a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043217450", 
          "https://doi.org/10.1038/306792a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329512a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046078048", 
          "https://doi.org/10.1038/329512a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.1983.tb01193.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049549943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00372673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051508014", 
          "https://doi.org/10.1007/bf00372673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2983425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062579163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7058332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062643410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1983.tb01413.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075014753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1983.tb01444.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075014785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077359145", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079444293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079492710", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079546474", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079675473", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079750403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079893709", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079940854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1985.tb04013.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080009537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb01900.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081856777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1984.tb01901.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081856778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082011018", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988-09", 
    "datePublishedReg": "1988-09-01", 
    "description": "The major histocompatibility complex (MHC) loci are known to be highly polymorphic in humans, mice and certain other mammals, with heterozygosity as high as 80-90% (ref. 1). Four different hypotheses have been proposed to explain this high degree of polymorphism: (1) a high mutation rate, (2) gene conversion or interlocus genetic exchange, (3) over dominant selection and (4) frequency-dependent selection. In an attempt to establish which of these hypotheses is correct, we examined the pattern of nucleotide substitution between polymorphic alleles in the region of the antigen recognition site (ARS) and other regions of human and mouse class I MHC genes. The results indicate that in ARS the rate of nonsynonymous (amino acid altering) substitution is significantly higher than that of synonymous substitution in both humans and mice, whereas in other regions the reverse is true. This observation, together with a theoretical study and other considerations, supports the hypothesis of overdominant selection (heterozygote advantage).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/335167a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6186", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "335"
      }
    ], 
    "name": "Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection", 
    "pagination": "167-170", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "aaf5d65896605556a1b376dae27a5b84af4ef7c2fc1577d00171d019beb8ecc2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3412472"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/335167a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035888295"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/335167a0", 
      "https://app.dimensions.ai/details/publication/pub.1035888295"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/335167a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/335167a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/335167a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/335167a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/335167a0'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      21 PREDICATES      73 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/335167a0 schema:about N01b1a116bd844c0b8b28dda2f1f9c5e1
2 N0e7dd5d2992941d0989e49d431872f03
3 N1e499d8f1262461f866b2542b5dd266e
4 N29bdb5d62f194153b5423793183378b4
5 N44b3d4264fec4d1392a30a6867fc90fb
6 N875d6eba6fe8430687532f34e550db55
7 Nb282db9dff824926a049d354d1586173
8 Nbeb91346ef6e4383a5e2e35c703c2ceb
9 Nc00d81d28969489eaf0531486f0af0bd
10 Neaf5bb232c614b72b1578c051d12a1d3
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N0d1b4537c5c14f098e783aa832edd2bf
14 schema:citation sg:pub.10.1007/bf00372673
15 sg:pub.10.1007/bf00376123
16 sg:pub.10.1007/bf00404424
17 sg:pub.10.1007/bf00404694
18 sg:pub.10.1007/bf00430802
19 sg:pub.10.1007/bf00430931
20 sg:pub.10.1038/211999a0
21 sg:pub.10.1038/237139a0
22 sg:pub.10.1038/256050a0
23 sg:pub.10.1038/306792a0
24 sg:pub.10.1038/326096a0
25 sg:pub.10.1038/329506a0
26 sg:pub.10.1038/329512a0
27 sg:pub.10.1038/332651a0
28 https://app.dimensions.ai/details/publication/pub.1077359145
29 https://app.dimensions.ai/details/publication/pub.1079492710
30 https://app.dimensions.ai/details/publication/pub.1079546474
31 https://app.dimensions.ai/details/publication/pub.1079675473
32 https://app.dimensions.ai/details/publication/pub.1079893709
33 https://app.dimensions.ai/details/publication/pub.1079940854
34 https://app.dimensions.ai/details/publication/pub.1082011018
35 https://doi.org/10.1002/j.1460-2075.1983.tb01413.x
36 https://doi.org/10.1002/j.1460-2075.1983.tb01444.x
37 https://doi.org/10.1002/j.1460-2075.1984.tb01900.x
38 https://doi.org/10.1002/j.1460-2075.1984.tb01901.x
39 https://doi.org/10.1002/j.1460-2075.1985.tb04013.x
40 https://doi.org/10.1016/s0065-2776(08)60229-1
41 https://doi.org/10.1093/nar/12.24.9473
42 https://doi.org/10.1093/oxfordjournals.molbev.a040333
43 https://doi.org/10.1093/oxfordjournals.molbev.a040410
44 https://doi.org/10.1097/00007890-198301000-00001
45 https://doi.org/10.1111/j.1399-0039.1983.tb01193.x
46 https://doi.org/10.1126/science.2983425
47 https://doi.org/10.1126/science.7058332
48 schema:datePublished 1988-09
49 schema:datePublishedReg 1988-09-01
50 schema:description The major histocompatibility complex (MHC) loci are known to be highly polymorphic in humans, mice and certain other mammals, with heterozygosity as high as 80-90% (ref. 1). Four different hypotheses have been proposed to explain this high degree of polymorphism: (1) a high mutation rate, (2) gene conversion or interlocus genetic exchange, (3) over dominant selection and (4) frequency-dependent selection. In an attempt to establish which of these hypotheses is correct, we examined the pattern of nucleotide substitution between polymorphic alleles in the region of the antigen recognition site (ARS) and other regions of human and mouse class I MHC genes. The results indicate that in ARS the rate of nonsynonymous (amino acid altering) substitution is significantly higher than that of synonymous substitution in both humans and mice, whereas in other regions the reverse is true. This observation, together with a theoretical study and other considerations, supports the hypothesis of overdominant selection (heterozygote advantage).
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N838c2487e2334c12a73955a75f53b3f7
55 N90814b0446444d4596d99169967159e2
56 sg:journal.1018957
57 schema:name Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
58 schema:pagination 167-170
59 schema:productId N05dc6b8dc0c24e229bf547ef138a91bf
60 N0dd25d17e1154b2a84587a184ba4fae8
61 N635d777e494a40518e9389a9f3b5d9ad
62 N82457d055af1461da97e613c1400f9b1
63 Nd3ed7f25585e4edea53ed7ef1a376760
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035888295
65 https://doi.org/10.1038/335167a0
66 schema:sdDatePublished 2019-04-10T13:56
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N47131cfa8f7d4162a7ed025935cb4c9c
69 schema:url http://www.nature.com/articles/335167a0
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N01b1a116bd844c0b8b28dda2f1f9c5e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Selection, Genetic
75 rdf:type schema:DefinedTerm
76 N05dc6b8dc0c24e229bf547ef138a91bf schema:name doi
77 schema:value 10.1038/335167a0
78 rdf:type schema:PropertyValue
79 N0d1b4537c5c14f098e783aa832edd2bf rdf:first sg:person.015075726302.00
80 rdf:rest Nabfeb2562d3340d4af0cec6657890650
81 N0dd25d17e1154b2a84587a184ba4fae8 schema:name readcube_id
82 schema:value aaf5d65896605556a1b376dae27a5b84af4ef7c2fc1577d00171d019beb8ecc2
83 rdf:type schema:PropertyValue
84 N0e7dd5d2992941d0989e49d431872f03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice
86 rdf:type schema:DefinedTerm
87 N1e499d8f1262461f866b2542b5dd266e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Genes, MHC Class I
89 rdf:type schema:DefinedTerm
90 N29bdb5d62f194153b5423793183378b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Polymorphism, Genetic
92 rdf:type schema:DefinedTerm
93 N44b3d4264fec4d1392a30a6867fc90fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Heterozygote
95 rdf:type schema:DefinedTerm
96 N47131cfa8f7d4162a7ed025935cb4c9c schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N635d777e494a40518e9389a9f3b5d9ad schema:name pubmed_id
99 schema:value 3412472
100 rdf:type schema:PropertyValue
101 N82457d055af1461da97e613c1400f9b1 schema:name nlm_unique_id
102 schema:value 0410462
103 rdf:type schema:PropertyValue
104 N838c2487e2334c12a73955a75f53b3f7 schema:volumeNumber 335
105 rdf:type schema:PublicationVolume
106 N875d6eba6fe8430687532f34e550db55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Models, Genetic
108 rdf:type schema:DefinedTerm
109 N90814b0446444d4596d99169967159e2 schema:issueNumber 6186
110 rdf:type schema:PublicationIssue
111 Nabfeb2562d3340d4af0cec6657890650 rdf:first sg:person.01365207531.88
112 rdf:rest rdf:nil
113 Nb282db9dff824926a049d354d1586173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Base Sequence
115 rdf:type schema:DefinedTerm
116 Nbeb91346ef6e4383a5e2e35c703c2ceb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 Nc00d81d28969489eaf0531486f0af0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 Nd3ed7f25585e4edea53ed7ef1a376760 schema:name dimensions_id
123 schema:value pub.1035888295
124 rdf:type schema:PropertyValue
125 Neaf5bb232c614b72b1578c051d12a1d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Exons
127 rdf:type schema:DefinedTerm
128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biological Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
132 schema:name Genetics
133 rdf:type schema:DefinedTerm
134 sg:journal.1018957 schema:issn 0090-0028
135 1476-4687
136 schema:name Nature
137 rdf:type schema:Periodical
138 sg:person.01365207531.88 schema:familyName Nei
139 schema:givenName M
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365207531.88
141 rdf:type schema:Person
142 sg:person.015075726302.00 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
143 schema:familyName Hughes
144 schema:givenName A L
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015075726302.00
146 rdf:type schema:Person
147 sg:pub.10.1007/bf00372673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051508014
148 https://doi.org/10.1007/bf00372673
149 rdf:type schema:CreativeWork
150 sg:pub.10.1007/bf00376123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028838770
151 https://doi.org/10.1007/bf00376123
152 rdf:type schema:CreativeWork
153 sg:pub.10.1007/bf00404424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010030284
154 https://doi.org/10.1007/bf00404424
155 rdf:type schema:CreativeWork
156 sg:pub.10.1007/bf00404694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024286205
157 https://doi.org/10.1007/bf00404694
158 rdf:type schema:CreativeWork
159 sg:pub.10.1007/bf00430802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004574038
160 https://doi.org/10.1007/bf00430802
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/bf00430931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018370195
163 https://doi.org/10.1007/bf00430931
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/211999a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000978459
166 https://doi.org/10.1038/211999a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/237139a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029056419
169 https://doi.org/10.1038/237139a0
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/256050a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023608866
172 https://doi.org/10.1038/256050a0
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/306792a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043217450
175 https://doi.org/10.1038/306792a0
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/326096a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040653168
178 https://doi.org/10.1038/326096a0
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/329506a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027347307
181 https://doi.org/10.1038/329506a0
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/329512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046078048
184 https://doi.org/10.1038/329512a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/332651a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013515235
187 https://doi.org/10.1038/332651a0
188 rdf:type schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1077359145 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1079492710 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1079546474 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1079675473 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079893709 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1079940854 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1082011018 schema:CreativeWork
196 https://doi.org/10.1002/j.1460-2075.1983.tb01413.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075014753
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/j.1460-2075.1983.tb01444.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075014785
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/j.1460-2075.1984.tb01900.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081856777
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/j.1460-2075.1984.tb01901.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081856778
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/j.1460-2075.1985.tb04013.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1080009537
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0065-2776(08)60229-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021864790
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/nar/12.24.9473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003635419
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/oxfordjournals.molbev.a040333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079444293
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/oxfordjournals.molbev.a040410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079750403
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1097/00007890-198301000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024759661
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1399-0039.1983.tb01193.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049549943
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1126/science.2983425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062579163
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1126/science.7058332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062643410
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.267308.8 schema:alternateName The University of Texas Health Science Center at Houston
223 schema:name Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...