Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-08-01

AUTHORS

Thomas W. Sturgill, L. Bryan Ray, Eleanor Erikson, James L. Maller

ABSTRACT

Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine residues in response to a variety of mitogens, including insulin, growth factors, and transforming proteins of many oncogenic viruses. Recently, an activated S6 kinase (S6 KII) has been purified to homogeneity from Xenopus eggs1, and characterized immunologically2 and at the molecular level3. Purified S6 KII can be deactivated in vitro by incubation with either protein phosphatase 1 or protein phosphatase 2A. Reactivation and phosphorylation of S6 KII occurs in vitro with an insulin-stimulated micro-tubule-associated protein-2 (MAP-2) protein kinase which is itself a phosphoprotein that can be deactivated by protein phosphatase 2A. These studies suggest that a step in insulin signalling involves sequential activation by phosphorylation of at least two serine/threonine protein kinases. More... »

PAGES

715-718

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/334715a0

DOI

http://dx.doi.org/10.1038/334715a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028437472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2842685


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoprotein Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribosomal Protein S6 Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenopus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA", 
          "id": "http://www.grid.ac/institutes/grid.27755.32", 
          "name": [
            "Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sturgill", 
        "givenName": "Thomas W.", 
        "id": "sg:person.0107140407.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107140407.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA", 
          "id": "http://www.grid.ac/institutes/grid.27755.32", 
          "name": [
            "Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ray", 
        "givenName": "L. Bryan", 
        "id": "sg:person.0665655330.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665655330.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA", 
          "id": "http://www.grid.ac/institutes/grid.241116.1", 
          "name": [
            "Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erikson", 
        "givenName": "Eleanor", 
        "id": "sg:person.0644021321.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644021321.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA", 
          "id": "http://www.grid.ac/institutes/grid.241116.1", 
          "name": [
            "Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maller", 
        "givenName": "James L.", 
        "id": "sg:person.0634071120.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634071120.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/320459a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045673168", 
          "https://doi.org/10.1038/320459a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-69075-4_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033076323", 
          "https://doi.org/10.1007/978-3-642-69075-4_5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988-08-01", 
    "datePublishedReg": "1988-08-01", 
    "description": "Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine residues in response to a variety of mitogens, including insulin, growth factors, and transforming proteins of many oncogenic viruses. Recently, an activated S6 kinase (S6 KII) has been purified to homogeneity from Xenopus eggs1, and characterized immunologically2 and at the molecular level3. Purified S6 KII can be deactivated in vitro by incubation with either protein phosphatase 1 or protein phosphatase 2A. Reactivation and phosphorylation of S6 KII occurs in vitro with an insulin-stimulated micro-tubule-associated protein-2 (MAP-2) protein kinase which is itself a phosphoprotein that can be deactivated by protein phosphatase 2A. These studies suggest that a step in insulin signalling involves sequential activation by phosphorylation of at least two serine/threonine protein kinases.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/334715a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6184", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "334"
      }
    ], 
    "keywords": [
      "protein phosphatase 2A.", 
      "phosphatase 2A.", 
      "protein kinase", 
      "ribosomal protein S6 kinase II", 
      "serine/threonine protein kinase", 
      "eukaryotic 40S ribosomal subunit", 
      "S6 kinase II", 
      "protein phosphatase 1", 
      "threonine protein kinase", 
      "multiple serine residues", 
      "ribosomal protein S6", 
      "phosphatase 1", 
      "serine residues", 
      "S6 kinase", 
      "protein S6", 
      "ribosomal subunit", 
      "kinase II", 
      "variety of mitogens", 
      "sequential activation", 
      "kinase", 
      "phosphorylation", 
      "growth factor", 
      "oncogenic viruses", 
      "phosphorylates", 
      "phosphoprotein", 
      "subunits", 
      "protein", 
      "S6", 
      "residues", 
      "mitogen", 
      "Eggs1", 
      "insulin", 
      "activation", 
      "virus", 
      "incubation", 
      "homogeneity", 
      "response", 
      "variety", 
      "level3", 
      "reactivation", 
      "components", 
      "factors", 
      "step", 
      "study", 
      "KII"
    ], 
    "name": "Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II", 
    "pagination": "715-718", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028437472"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/334715a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2842685"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/334715a0", 
      "https://app.dimensions.ai/details/publication/pub.1028437472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_195.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/334715a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/334715a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/334715a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/334715a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/334715a0'


 

This table displays all metadata directly associated to this object as RDF triples.

194 TRIPLES      21 PREDICATES      86 URIs      76 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/334715a0 schema:about N121cea53c4ab4cb9ae75ac857a8c3edb
2 N194abb39743448c8806c4a56c16f8163
3 N22a06631c9324121844e20627869c3c3
4 N292696c4e37a4bfa87f3c86dbfb951d8
5 N367e983e810940c2889207c5a882d830
6 N4975c29c98fe4a01b73bc345e5f87214
7 N6f74b79e03d64c25a335e04ba5d84111
8 N7dbaccec28654bdba95ed1665c76310d
9 N911aaf6318fa41f4bf77cd7eb87321b2
10 Nc5090a60df6a427fa2101be826e015be
11 Ncdef412865d64fe2ad15810267923277
12 Nd7cca2ebfd3b4d9b9ec434d30a3e254b
13 Nf34b1b53a4814e0a9ad9a723e2445c77
14 Nf4f27819152c4bd9ab5586f155ccb7b1
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author N49ece43128764a28955ca774a6e840fe
18 schema:citation sg:pub.10.1007/978-3-642-69075-4_5
19 sg:pub.10.1038/320459a0
20 schema:datePublished 1988-08-01
21 schema:datePublishedReg 1988-08-01
22 schema:description Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine residues in response to a variety of mitogens, including insulin, growth factors, and transforming proteins of many oncogenic viruses. Recently, an activated S6 kinase (S6 KII) has been purified to homogeneity from Xenopus eggs1, and characterized immunologically2 and at the molecular level3. Purified S6 KII can be deactivated in vitro by incubation with either protein phosphatase 1 or protein phosphatase 2A. Reactivation and phosphorylation of S6 KII occurs in vitro with an insulin-stimulated micro-tubule-associated protein-2 (MAP-2) protein kinase which is itself a phosphoprotein that can be deactivated by protein phosphatase 2A. These studies suggest that a step in insulin signalling involves sequential activation by phosphorylation of at least two serine/threonine protein kinases.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf Nc71ec72c0e7a47b19c1f89b42c6afd74
26 Ne4bae264c191414cba1c799d298a7091
27 sg:journal.1018957
28 schema:keywords Eggs1
29 KII
30 S6
31 S6 kinase
32 S6 kinase II
33 activation
34 components
35 eukaryotic 40S ribosomal subunit
36 factors
37 growth factor
38 homogeneity
39 incubation
40 insulin
41 kinase
42 kinase II
43 level3
44 mitogen
45 multiple serine residues
46 oncogenic viruses
47 phosphatase 1
48 phosphatase 2A.
49 phosphoprotein
50 phosphorylates
51 phosphorylation
52 protein
53 protein S6
54 protein kinase
55 protein phosphatase 1
56 protein phosphatase 2A.
57 reactivation
58 residues
59 response
60 ribosomal protein S6
61 ribosomal protein S6 kinase II
62 ribosomal subunit
63 sequential activation
64 serine residues
65 serine/threonine protein kinase
66 step
67 study
68 subunits
69 threonine protein kinase
70 variety
71 variety of mitogens
72 virus
73 schema:name Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
74 schema:pagination 715-718
75 schema:productId N2629de361a2e460e9d6e6986d0d2bb09
76 N8880a08185ca46e3a919f3afa89793fb
77 Nee632f66cc814774a26581d67320532d
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028437472
79 https://doi.org/10.1038/334715a0
80 schema:sdDatePublished 2022-09-02T15:46
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N380149fb8fd7420db65b81ed2bda82e8
83 schema:url https://doi.org/10.1038/334715a0
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N121cea53c4ab4cb9ae75ac857a8c3edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Female
89 rdf:type schema:DefinedTerm
90 N194abb39743448c8806c4a56c16f8163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N22a06631c9324121844e20627869c3c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Protein Kinases
95 rdf:type schema:DefinedTerm
96 N23098dd088fc4ea3a31abf3cc555d534 rdf:first sg:person.0634071120.21
97 rdf:rest rdf:nil
98 N2629de361a2e460e9d6e6986d0d2bb09 schema:name pubmed_id
99 schema:value 2842685
100 rdf:type schema:PropertyValue
101 N292696c4e37a4bfa87f3c86dbfb951d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Xenopus
103 rdf:type schema:DefinedTerm
104 N367e983e810940c2889207c5a882d830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Phosphoprotein Phosphatases
106 rdf:type schema:DefinedTerm
107 N380149fb8fd7420db65b81ed2bda82e8 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N4975c29c98fe4a01b73bc345e5f87214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Calcium-Calmodulin-Dependent Protein Kinases
111 rdf:type schema:DefinedTerm
112 N49ece43128764a28955ca774a6e840fe rdf:first sg:person.0107140407.03
113 rdf:rest Nfa3a2947e82f46739422dbab1c0b4064
114 N6f74b79e03d64c25a335e04ba5d84111 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cell Line
116 rdf:type schema:DefinedTerm
117 N7dbaccec28654bdba95ed1665c76310d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Phosphorylation
119 rdf:type schema:DefinedTerm
120 N8880a08185ca46e3a919f3afa89793fb schema:name dimensions_id
121 schema:value pub.1028437472
122 rdf:type schema:PropertyValue
123 N911aaf6318fa41f4bf77cd7eb87321b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Oocytes
125 rdf:type schema:DefinedTerm
126 Nb7bce7435f75487aa0a680f057a8fcd8 rdf:first sg:person.0644021321.82
127 rdf:rest N23098dd088fc4ea3a31abf3cc555d534
128 Nc5090a60df6a427fa2101be826e015be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Protein Phosphatase 1
130 rdf:type schema:DefinedTerm
131 Nc71ec72c0e7a47b19c1f89b42c6afd74 schema:issueNumber 6184
132 rdf:type schema:PublicationIssue
133 Ncdef412865d64fe2ad15810267923277 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Insulin
135 rdf:type schema:DefinedTerm
136 Nd7cca2ebfd3b4d9b9ec434d30a3e254b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Protein Phosphatase 2
138 rdf:type schema:DefinedTerm
139 Ne4bae264c191414cba1c799d298a7091 schema:volumeNumber 334
140 rdf:type schema:PublicationVolume
141 Nee632f66cc814774a26581d67320532d schema:name doi
142 schema:value 10.1038/334715a0
143 rdf:type schema:PropertyValue
144 Nf34b1b53a4814e0a9ad9a723e2445c77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ribosomal Protein S6 Kinases
146 rdf:type schema:DefinedTerm
147 Nf4f27819152c4bd9ab5586f155ccb7b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Enzyme Activation
149 rdf:type schema:DefinedTerm
150 Nfa3a2947e82f46739422dbab1c0b4064 rdf:first sg:person.0665655330.07
151 rdf:rest Nb7bce7435f75487aa0a680f057a8fcd8
152 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
153 schema:name Biological Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biochemistry and Cell Biology
157 rdf:type schema:DefinedTerm
158 sg:journal.1018957 schema:issn 0028-0836
159 1476-4687
160 schema:name Nature
161 schema:publisher Springer Nature
162 rdf:type schema:Periodical
163 sg:person.0107140407.03 schema:affiliation grid-institutes:grid.27755.32
164 schema:familyName Sturgill
165 schema:givenName Thomas W.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0107140407.03
167 rdf:type schema:Person
168 sg:person.0634071120.21 schema:affiliation grid-institutes:grid.241116.1
169 schema:familyName Maller
170 schema:givenName James L.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634071120.21
172 rdf:type schema:Person
173 sg:person.0644021321.82 schema:affiliation grid-institutes:grid.241116.1
174 schema:familyName Erikson
175 schema:givenName Eleanor
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644021321.82
177 rdf:type schema:Person
178 sg:person.0665655330.07 schema:affiliation grid-institutes:grid.27755.32
179 schema:familyName Ray
180 schema:givenName L. Bryan
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665655330.07
182 rdf:type schema:Person
183 sg:pub.10.1007/978-3-642-69075-4_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033076323
184 https://doi.org/10.1007/978-3-642-69075-4_5
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/320459a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045673168
187 https://doi.org/10.1038/320459a0
188 rdf:type schema:CreativeWork
189 grid-institutes:grid.241116.1 schema:alternateName Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA
190 schema:name Department of Pharmacology, University of Colorado School of Medicine, 80262, Denver, Colorado, USA
191 rdf:type schema:Organization
192 grid-institutes:grid.27755.32 schema:alternateName Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA
193 schema:name Departments of Internal Medicine and Pharmacology, University of Virginia School of Medicine, 22903, Charlottesville, Virginia, USA
194 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...