Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-06

AUTHORS

W Weis, J H Brown, S Cusack, J C Paulson, J J Skehel, D C Wiley

ABSTRACT

The three-dimensional structures of influenza virus haemagglutinins complexed with cell receptor analogues show sialic acids bound to a pocket of conserved amino acids surrounded by antibody-binding sites. Sialic acid fills the conserved pocket, demonstrating that it is the influenza virus receptor. The proximity of the antibody-binding sites suggests that antibodies neutralize virus infectivity by preventing virus-to-cell binding. The structures suggest approaches to the design of anti-viral drugs that could block attachment of viruses to cells. More... »

PAGES

426-431

Journal

TITLE

Nature

ISSUE

6172

VOLUME

333

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/333426a0

    DOI

    http://dx.doi.org/10.1038/333426a0

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3374584


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