Cingulin, a new peripheral component of tight junctions View Full Text


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Article Info

DATE

1988-05

AUTHORS

Sandra Citi, Helena Sabanay, Ross Jakes, Benjamin Geiger, John Kendrick-Jones

ABSTRACT

The tight junction (zonula occludens), a belt-like region of contact between cells of polarized epithelia, serves as a selective barrier to small molecules and as a total barrier to large molecules1,2, and is involved in the separation between lumenal and basolateral compartments of the epithelium3,4. In the electron microscope, tight junctions show focal regions of apparent fusion between the adjoining cell membranes, and freeze-fractured membranes display an elaborate network of branching and anastomosing strands1,5–8. Very little is known about the molecular composition and architecture of tight junctions. The first specific zonula occludens-associated protein, designated ZO-1, has recently been identified in mammalian epithelial and endothelial cells9. Here we describe the identification and purification of a new component of this junc-tional complex in avian brush-border cells, which we name cingulin. Cingulin is an acidic, heat-stable protein, with a highly elongated shape. Immunofluorescence and immunoelectron microscopy of brush-border cells with anti-cingulin antibodies show that cingulin is localized in the apical zone of the terminal web, at the endofacial surfaces of the zonula occludens. More... »

PAGES

272-276

References to SciGraph publications

  • 1982-04. Evidence for the lipidic nature of tight junction strands in NATURE
  • 1985-12. The thin filaments of smooth muscles in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/333272a0

    DOI

    http://dx.doi.org/10.1038/333272a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046830196

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3285223


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