A novel viral oncogene with structural similarity to phospholipase C View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-03

AUTHORS

B J Mayer, M Hamaguchi, H Hanafusa

ABSTRACT

Numerous oncogenes have been isolated from acutely transforming retroviruses. To date, the products of these viral oncogenes have been protein kinases, nuclear proteins, growth factors, or GTP-binding proteins. We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome. This virus encodes a protein, p47gag-crk, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. In addition, the structure of p47gag-crk has striking similarity to a 180-amino acid region of bovine brain phospholipase C. Biochemical data suggest that p47gag-crk activates one or several endogenous tyrosine kinases. More... »

PAGES

272-275

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6161

VOLUME

332

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/332272a0

    DOI

    http://dx.doi.org/10.1038/332272a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037158467

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2450282


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