Brain-derived neurotrophic factor prevents neuronal death in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-01

AUTHORS

M. M. Hofer, Y.-A. Barde

ABSTRACT

Developing vertebrate neurons are thought to depend for their survival on specific neurotrophic proteins present in their target fields1. The limited availability of these proteins does not allow the survival of all neurons initially innervating a target, resulting in the widely observed phenomenon of naturally occurring neuronal death1. Although a variety of proteins have been reported to promote the survival of neurons in tissue culture2–4, the demonstration that these proteins increase neuronal numbers and/or decrease neuronal death in vivo has only been possible with nerve growth factor (NGF)5–7. The generalization of the concept that neurotrophic proteins regulate neuronal survival during normal development critically depends on the demonstration that the survival of neurons in vivo can be increased by the administration of a neurotrophic protein different from NGF. We report here that this is the case with brain-derived neurotrophic factor, a protein of extremely low abundance purified from the central nervous system. More... »

PAGES

261-262

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/331261a0

DOI

http://dx.doi.org/10.1038/331261a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004547388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3336438


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