A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-12

AUTHORS

H de Thé, A Marchio, P Tiollais, A Dejean

ABSTRACT

We have previously isolated from a human hepatocellular carcinoma a hepatitis B virus integration in a 147-base-pair cellular DNA fragment, similar to steroid- and c-erb-A/thyroid-hormone receptor genes. We have now cloned the corresponding complementary DNA from a human-liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which we have named hap, is similar to that of the DNA-binding hormone receptors. That is, it displays two highly conserved regions identified as the putative DNA-binding and hormone-binding domains of the c-erb A/steroid receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5-kilobase (kb) hap messenger RNA species which is undetectable in normal adult and fetal livers but present in all non-hepatic tissues analysed. The data suggest that the hap gene product may be a novel ligand-responsive regulatory protein whose inappropriate expression in liver may relate to the hepatocellular carcinogenesis. More... »

PAGES

667-670

Journal

TITLE

Nature

ISSUE

6149

VOLUME

330

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/330667a0

DOI

http://dx.doi.org/10.1038/330667a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027111675

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2825037


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