Neurogenesis in the adult human hippocampus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-11

AUTHORS

Peter S. Eriksson, Ekaterina Perfilieva, Thomas Björk-Eriksson, Ann-Marie Alborn, Claes Nordborg, Daniel A. Peterson, Fred H. Gage

ABSTRACT

The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, in regions previously identified as neurogenic in adult rodents and monkeys. Human brain tissue was obtained postmortem from patients who had been treated with the thymidine analog, bromodeoxyuridine (BrdU), that labels DNA during the S phase. Using immunofluorescent labeling for BrdU and for one of the neuronal markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans. Our results further indicate that the human hippocampus retains its ability to generate neurons throughout life. More... »

PAGES

nm1198_1313

Journal

TITLE

Nature Medicine

ISSUE

11

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/3305

    DOI

    http://dx.doi.org/10.1038/3305

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035614683

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9809557


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    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/3305'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/3305'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/3305'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/3305'


     

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