Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-10

AUTHORS

Michelle Hadchouel, Hend Farza, Dominique Simon, Pierre Tiollais, Christine Pourcel

ABSTRACT

Differential modifications of the genome during gametogenesis result in a functional difference between the paternal and maternal genomes at the moment of fertilization1–4. A possible cause of this imprinting is the methylation of DNA5,6. The insertion of foreign DNA into transgenic mice allows the tagging of regions that are differentially methylated during gametogenesis. We describe here a transgenic mouse strain in which the expression of the hepatitis B surface antigen gene is irreversibly repressed following its passage through the female germ line. This inhibition is accompanied by the methylation of all the HpaII and HhaI sites within the foreign gene, which we have shown to be integrated into a site on chromosome 13. The irreversibility reported here contrasts with what is found with other transgenic mice sequences which are reversibly methylated after passage through the male or female germ line7,8, though in both cases methylation appears to be important in the imprinting process. More... »

PAGES

454-456

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/329454a0

DOI

http://dx.doi.org/10.1038/329454a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052331842

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2443854


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