Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-11

AUTHORS

J. Michael Kilby, Sam Hopkins, Thomas M. Venetta, Betty DiMassimo, Gretchen A. Cloud, Jeannette Y. Lee, Leslie Alldredge, Eric Hunter, Dennis Lambert, Dani Bolognesi, Thomas Matthews, M. Ross Johnson, Martin A. Nowak, George M. Shaw, Michael S. Saag

ABSTRACT

T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-1 envelope protein, blocks cell fusion and viral entry at concentrations of less than 2 ng/ml in vitro. We administered intravenous T-20 (monotherapy) for 14 days to sixteen HIV-infected adults in four dose groups (3, 10, 30 and 100 mg twice daily). There were significant, dose-related declines in plasma HIV RNA in all subjects who received higher dose levels. All four subjects receiving 100 mg twice daily had a decline in plasma HIV RNA to less than 500 copies/ml, by bDNA assay. A sensitive RT–PCR assay (detection threshold 40 copies/ml) demonstrated that, although undetectable levels were not achieved in the 14-day dosing period, there was a 1.96 log10 median decline in plasma HIV RNA in these subjects. This study provides proof-of-concept that viral entry can be successfully blocked in vivo. Short-term administration of T-20 seems safe and provides potent inhibition of HIV replication comparable to anti-retroviral regimens approved at present. More... »

PAGES

1302-1307

Journal

TITLE

Nature Medicine

ISSUE

11

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/3293

    DOI

    http://dx.doi.org/10.1038/3293

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053214876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9809555


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    321 grid-institutes:grid.422716.4 schema:alternateName Trimeris, Inc., 4727 University Drive, 27707, Durham, North Carolina, USA
    322 schema:name Trimeris, Inc., 4727 University Drive, 27707, Durham, North Carolina, USA
    323 rdf:type schema:Organization
     




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