Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-11

AUTHORS

J M Kilby, S Hopkins, T M Venetta, B DiMassimo, G A Cloud, J Y Lee, L Alldredge, E Hunter, D Lambert, D Bolognesi, T Matthews, M R Johnson, M A Nowak, G M Shaw, M S Saag

ABSTRACT

T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-1 envelope protein, blocks cell fusion and viral entry at concentrations of less than 2 ng/ml in vitro. We administered intravenous T-20 (monotherapy) for 14 days to sixteen HIV-infected adults in four dose groups (3, 10, 30 and 100 mg twice daily). There were significant, dose-related declines in plasma HIV RNA in all subjects who received higher dose levels. All four subjects receiving 100 mg twice daily had a decline in plasma HIV RNA to less than 500 copies/ml, by bDNA assay. A sensitive RT-PCR assay (detection threshold 40 copies/ml) demonstrated that, although undetectable levels were not achieved in the 14-day dosing period, there was a 1.96 log10 median decline in plasma HIV RNA in these subjects. This study provides proof-of-concept that viral entry can be successfully blocked in vivo. Short-term administration of T-20 seems safe and provides potent inhibition of HIV replication comparable to anti-retroviral regimens approved at present. More... »

PAGES

1302-1307

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

11

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/3293

    DOI

    http://dx.doi.org/10.1038/3293

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053214876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9809555


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