Functional inactivation of genes by dominant negative mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-09

AUTHORS

Ira Herskowitz

ABSTRACT

Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new approach to this problem involves the manipulation of the cloned gene to create what are known as 'dominant negative' mutations. These encode mutant polypeptides that when overexpressed disrupt the activity of the wild-type gene. There are many precedents for this kind of behaviour in the literature--some oncogenes might be examples of naturally occurring dominant negative mutations. More... »

PAGES

219-222

Journal

TITLE

Nature

ISSUE

6136

VOLUME

329

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/329219a0

    DOI

    http://dx.doi.org/10.1038/329219a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005321784

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2442619


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