A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-03

AUTHORS

K Clément, C Vaisse, N Lahlou, S Cabrol, V Pelloux, D Cassuto, M Gourmelen, C Dina, J Chambaz, J M Lacorte, A Basdevant, P Bougnères, Y Lebouc, P Froguel, B Guy-Grand

ABSTRACT

The adipocyte-specific hormone leptin, the product of the obese (ob) gene, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure. Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family. In rodents, homozygous mutations in genes encoding leptin or the leptin receptor cause early-onset morbid obesity, hyperphagia and reduced energy expenditure. These rodents also show hypercortisolaemia, alterations in glucose homeostasis, dyslipidaemia, and infertility due to hypogonadotropic hypogonadisms. In humans, leptin deficiency due to a mutation in the leptin gene is associated with early-onset obesity. Here we describe a homozygous mutation in the human leptin receptor gene that results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains. In addition to their early-onset morbid obesity, patients homozygous for this mutation have no pubertal development and their secretion of growth hormone and thyrotropin is reduced. These results indicate that leptin is an important physiological regulator of several endocrine functions in humans. More... »

PAGES

398-401

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/32911

DOI

http://dx.doi.org/10.1038/32911

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028658791

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9537324


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N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/32911'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/32911'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/32911'


 

This table displays all metadata directly associated to this object as RDF triples.

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