Association of DNA-bound progesterone receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-09

AUTHORS

Bernard Théveny, Alain Bailly, Claudine Rauch, Michel Rauch, Etienne Delain, Edwin Milgrom

ABSTRACT

Steroid hormone–receptor complexes regulate the transcription of specific genes. Recent studies of high-affinity interactions between the receptors and discrete regions of DNA, together with gene-transfer experiments, have led to the precise mapping of hormone regulatory elements1,2. Nothing is known, however, about the mechanisms whereby DNA-bound receptors modulate gene transcription. At the start of transcription in prokaryotes two oligomeric molecules of several regulatory proteins must bind to two specific DNA sites and interact with one another to regulate the binding of RNA polymerase to DNA3,4. Using electron microscopy to observe progesterone receptor binding to regulatory regions of uteroglobin and mouse mammary tumour virus genes, we demonstrate a similar binding between receptor oligomers at two DNA sites. DNA loops are formed when the hormone regulatory elements are at a distance from one another. Thus, in common with certain prokaryotic systems, protein–protein interactions may be important in steroid hormone regulation of gene transcription. More... »

PAGES

79-81

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/329079a0

DOI

http://dx.doi.org/10.1038/329079a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041206452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3041228


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