Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-08

AUTHORS

Howard R. Morris, Graham W. Taylor, Mark S. Masento, Keith A. Jermyn, Robert R. Kay

ABSTRACT

Morphogens are signal molecules presumed to exist in embryos and to be involved in establishing the spatial pattern of cells during development. Differentiation inducing factor (DIF) has the properties of a morphogen required for producing the prestalk/prespore pattern in the aggregate formed by cells of the slime mould Dictyostelium in response to starvation. DIF-1, the major bioactive species after purification, has now been identified using a combined microchemical, spectroscopic and synthetic approach. The structure is defined as 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, and represents a new class of effector molecule. The availability of relatively large quantities of synthetic and isotopically labelled materials should now allow progress towards a detailed understanding of the pattern-forming processes in Dictyostelium development. More... »

PAGES

811-814

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/328811a0

DOI

http://dx.doi.org/10.1038/328811a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023133150

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3627228


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