Possible positive autocrine feedback in the prereplicative phase of human fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-08

AUTHORS

Annet Hammacher, Bengt Westermark, Carl-Henrik Heldin, Ylva Paulsson

ABSTRACT

The growth of normal diploid fibroblasts is generally thought to be tightly controlled by exogenous growth factors such as platelet-derived growth factor (PDGF) and epidermal growth factor (EGF). Subversion of a growth factor pathway at a regulatory point is considered to be a key event in neoplastic transformation and tumorigenesis. Thus, simian sarcoma virus has acquired the gene encoding the B-chain of PDGF and there is direct experimental proof that SSV-transformation is mediated by a PDGF-like growth factor. There is accumulating evidence that PDGF-like molecules are also synthesized and released by certain normal cells, suggesting an important role of cellularly produced PDGF in development and tissue regeneration. We now present evidence that a transient expression of the gene encoding the PDGF A-chain, and the synthesis and release of functional A-chain homodimers, is an early event in the prereplicative phase of normal human foreskin fibroblasts exposed to PDGF or EGF. Since these cells are PDGF-responsive, the results imply the existence of a positive autocrine signal that may serve as an amplifier of the mitogenic response under certain conditions. More... »

PAGES

715

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/328715a0

DOI

http://dx.doi.org/10.1038/328715a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1056438833

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3497351


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