Host origin of marrow stromal cells following allogeneic bone marrow transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

Paul J. Simmons, Donna Przepiorka, E. Donnall Thomas, Beverley Torok-Storb

ABSTRACT

Although it is generally agreed that stromal cells are important in the regulation of haematopoietic cell development, the origin of these phenotypically diverse cells has been a subject for debate for more than 50 years. Data which support the concept of a separate origin for the haematopoietic stem cell and the marrow stroma are derived from cytogenetic or enzyme marker studies of explanted and expanded stromal cells grown under conditions that do not allow haematopoiesis in vitro. Recent evidence in man and in mouse suggesting that the stromal cells capable of transferring the haematopoietic microenvironment in vitro are transplantable seemingly questions this dichotomy, one interpretation being the existence of a common haematopoietic/stromal 'stem cell'. We used in situ hybridization to discriminate donor cells from host in blood and bone marrow samples obtained from patients with functioning sex-mismatched but HLA-identical allografts. Without exception, marrow-derived stromal cells that proliferate in long-term cultures were found to be of host genotype, whereas the macrophage component of the adherent layer in these cultures originated from the donor. More... »

PAGES

429-432

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/328429a0

DOI

http://dx.doi.org/10.1038/328429a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1056438812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2886914


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