Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

G Y Hu, O Hvalby, S I Walaas, K A Albert, P Skjeflo, P Andersen, P Greengard

ABSTRACT

Long-term potentiation (LTP) in the hippocampus is an interesting example of synaptic plasticity because of its induction by physiological discharge rates and its long duration. Of the possible biochemical mechanisms that regulate prolonged changes in cell function, protein phosphorylation is a particularly attractive candidate. We have therefore examined the effect of intracellular injection of calcium/diacylglycerol-dependent protein kinase (protein kinase C (PKC] in CA1 pyramidal neurones in hippocampal slices. Injection of the active enzyme elicited long-lasting enhancement of synaptic transmission, similar to LTP, whereas inactivated kinase failed to do so. The observed changes included an increased amplitude of the excitatory post-synaptic potential (e.p.s.p.) and an increased probability of firing and a reduced latency of the associated actin potential. More... »

PAGES

426-429

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/328426a0

DOI

http://dx.doi.org/10.1038/328426a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1056438811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3614346


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Hu", 
        "givenName": "G Y", 
        "id": "sg:person.01263646247.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263646247.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hvalby", 
        "givenName": "O", 
        "id": "sg:person.01035366227.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035366227.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Walaas", 
        "givenName": "S I", 
        "id": "sg:person.01152732002.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152732002.05"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Albert", 
        "givenName": "K A", 
        "id": "sg:person.01144277525.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144277525.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Skjeflo", 
        "givenName": "P", 
        "type": "Person"
      }, 
      {
        "familyName": "Andersen", 
        "givenName": "P", 
        "id": "sg:person.01356024554.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356024554.61"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Greengard", 
        "givenName": "P", 
        "id": "sg:person.01336620154.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336620154.37"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1987-07", 
    "datePublishedReg": "1987-07-01", 
    "description": "Long-term potentiation (LTP) in the hippocampus is an interesting example of synaptic plasticity because of its induction by physiological discharge rates and its long duration. Of the possible biochemical mechanisms that regulate prolonged changes in cell function, protein phosphorylation is a particularly attractive candidate. We have therefore examined the effect of intracellular injection of calcium/diacylglycerol-dependent protein kinase (protein kinase C (PKC] in CA1 pyramidal neurones in hippocampal slices. Injection of the active enzyme elicited long-lasting enhancement of synaptic transmission, similar to LTP, whereas inactivated kinase failed to do so. The observed changes included an increased amplitude of the excitatory post-synaptic potential (e.p.s.p.) and an increased probability of firing and a reduced latency of the associated actin potential.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/328426a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6129", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "328"
      }
    ], 
    "name": "Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation", 
    "pagination": "426-429", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "eaebac707ce4b9735a95008cb1038b98aacefb5d08c43f9146c56c250edb29c1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3614346"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/328426a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1056438811"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/328426a0", 
      "https://app.dimensions.ai/details/publication/pub.1056438811"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/328426a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/328426a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/328426a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/328426a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/328426a0'


 

This table displays all metadata directly associated to this object as RDF triples.

132 TRIPLES      20 PREDICATES      37 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/328426a0 schema:about N245e28b0215440fd8475806fc06c3ce3
2 N3cc1a0a2d23744f982455df8d39ddda2
3 Nba1a4dd9ac494f4db732e4bb6fcf5e3c
4 Nc463ecc52bc54b6889b390fe462ba1ad
5 Nd45791824f004e90952abf46160e054e
6 Ndfcaafb0ba2c49d08e8156bbf3c83415
7 Ne095f474709b4b988936dc8cba2197db
8 Ne630475a5db04605bb56c2459f555dde
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author Nc43b536ebd12400e83a2a50b22de5d67
12 schema:datePublished 1987-07
13 schema:datePublishedReg 1987-07-01
14 schema:description Long-term potentiation (LTP) in the hippocampus is an interesting example of synaptic plasticity because of its induction by physiological discharge rates and its long duration. Of the possible biochemical mechanisms that regulate prolonged changes in cell function, protein phosphorylation is a particularly attractive candidate. We have therefore examined the effect of intracellular injection of calcium/diacylglycerol-dependent protein kinase (protein kinase C (PKC] in CA1 pyramidal neurones in hippocampal slices. Injection of the active enzyme elicited long-lasting enhancement of synaptic transmission, similar to LTP, whereas inactivated kinase failed to do so. The observed changes included an increased amplitude of the excitatory post-synaptic potential (e.p.s.p.) and an increased probability of firing and a reduced latency of the associated actin potential.
15 schema:genre research_article
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf N93e7d44e85d74038999821c2b33b42b8
19 Nbdaf1094efb749cbb3658c0e5a483397
20 sg:journal.1018957
21 schema:name Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation
22 schema:pagination 426-429
23 schema:productId N464d77d87c8d441d91b7c898715fc8ad
24 Nc181be39ccb243a78c5cbacded888b89
25 Ne0710089cfa84a6bb34f657b7dbeac70
26 Ne3d0b962f5254a58829b15f4932132dd
27 Nf5e80347a0b945448cb098a133eddadd
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056438811
29 https://doi.org/10.1038/328426a0
30 schema:sdDatePublished 2019-04-10T18:08
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N9813cf0c3a86412eaf6e53e196ad5239
33 schema:url http://www.nature.com/articles/328426a0
34 sgo:license sg:explorer/license/
35 sgo:sdDataset articles
36 rdf:type schema:ScholarlyArticle
37 N11118c4caa784575ba83601da5dfe9a3 rdf:first sg:person.01152732002.05
38 rdf:rest N201543472c694e4f87e377df1f88473d
39 N1c84c7aa5d6a4c00ba0932ecb40dae23 rdf:first sg:person.01356024554.61
40 rdf:rest N62e04bbd0edf4a7ebe29a80ef1b86522
41 N201543472c694e4f87e377df1f88473d rdf:first sg:person.01144277525.21
42 rdf:rest Ncd2f96a07b224b19b1456eef7488d89a
43 N245e28b0215440fd8475806fc06c3ce3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
44 schema:name Action Potentials
45 rdf:type schema:DefinedTerm
46 N367af4b5824348d2b9ca94ba1a6181b2 schema:familyName Skjeflo
47 schema:givenName P
48 rdf:type schema:Person
49 N3cc1a0a2d23744f982455df8d39ddda2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
50 schema:name Hippocampus
51 rdf:type schema:DefinedTerm
52 N464d77d87c8d441d91b7c898715fc8ad schema:name dimensions_id
53 schema:value pub.1056438811
54 rdf:type schema:PropertyValue
55 N62e04bbd0edf4a7ebe29a80ef1b86522 rdf:first sg:person.01336620154.37
56 rdf:rest rdf:nil
57 N67b16929f11246d6b2a67247a136a5d1 rdf:first sg:person.01035366227.12
58 rdf:rest N11118c4caa784575ba83601da5dfe9a3
59 N93e7d44e85d74038999821c2b33b42b8 schema:issueNumber 6129
60 rdf:type schema:PublicationIssue
61 N9813cf0c3a86412eaf6e53e196ad5239 schema:name Springer Nature - SN SciGraph project
62 rdf:type schema:Organization
63 Nba1a4dd9ac494f4db732e4bb6fcf5e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Protein Kinase C
65 rdf:type schema:DefinedTerm
66 Nbdaf1094efb749cbb3658c0e5a483397 schema:volumeNumber 328
67 rdf:type schema:PublicationVolume
68 Nc181be39ccb243a78c5cbacded888b89 schema:name doi
69 schema:value 10.1038/328426a0
70 rdf:type schema:PropertyValue
71 Nc43b536ebd12400e83a2a50b22de5d67 rdf:first sg:person.01263646247.40
72 rdf:rest N67b16929f11246d6b2a67247a136a5d1
73 Nc463ecc52bc54b6889b390fe462ba1ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Synapses
75 rdf:type schema:DefinedTerm
76 Ncd2f96a07b224b19b1456eef7488d89a rdf:first N367af4b5824348d2b9ca94ba1a6181b2
77 rdf:rest N1c84c7aa5d6a4c00ba0932ecb40dae23
78 Nd45791824f004e90952abf46160e054e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Animals
80 rdf:type schema:DefinedTerm
81 Ndfcaafb0ba2c49d08e8156bbf3c83415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Enzyme Activation
83 rdf:type schema:DefinedTerm
84 Ne0710089cfa84a6bb34f657b7dbeac70 schema:name nlm_unique_id
85 schema:value 0410462
86 rdf:type schema:PropertyValue
87 Ne095f474709b4b988936dc8cba2197db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Membrane Potentials
89 rdf:type schema:DefinedTerm
90 Ne3d0b962f5254a58829b15f4932132dd schema:name readcube_id
91 schema:value eaebac707ce4b9735a95008cb1038b98aacefb5d08c43f9146c56c250edb29c1
92 rdf:type schema:PropertyValue
93 Ne630475a5db04605bb56c2459f555dde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Rats
95 rdf:type schema:DefinedTerm
96 Nf5e80347a0b945448cb098a133eddadd schema:name pubmed_id
97 schema:value 3614346
98 rdf:type schema:PropertyValue
99 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
100 schema:name Biological Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
103 schema:name Biochemistry and Cell Biology
104 rdf:type schema:DefinedTerm
105 sg:journal.1018957 schema:issn 0090-0028
106 1476-4687
107 schema:name Nature
108 rdf:type schema:Periodical
109 sg:person.01035366227.12 schema:familyName Hvalby
110 schema:givenName O
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035366227.12
112 rdf:type schema:Person
113 sg:person.01144277525.21 schema:familyName Albert
114 schema:givenName K A
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144277525.21
116 rdf:type schema:Person
117 sg:person.01152732002.05 schema:familyName Walaas
118 schema:givenName S I
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152732002.05
120 rdf:type schema:Person
121 sg:person.01263646247.40 schema:familyName Hu
122 schema:givenName G Y
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263646247.40
124 rdf:type schema:Person
125 sg:person.01336620154.37 schema:familyName Greengard
126 schema:givenName P
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336620154.37
128 rdf:type schema:Person
129 sg:person.01356024554.61 schema:familyName Andersen
130 schema:givenName P
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356024554.61
132 rdf:type schema:Person
 




Preview window. Press ESC to close (or click here)


...