AIDS virus-specific cytotoxic T lymphocytes in lung disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

Fernando Plata, Brigitte Autran, Livia Pedroza Martins, Simon Wain-Hobson, Martine Raphaël, Charles Mayaud, Michel Denis, Jean-Marc Guillon, Patrice Debré

ABSTRACT

Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome). HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans and apes. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CD8 surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients. More... »

PAGES

348-351

Journal

TITLE

Nature

ISSUE

6128

VOLUME

328

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/328348a0

    DOI

    http://dx.doi.org/10.1038/328348a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030563313

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3496542


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