HIV-specific cytotoxic T lymphocytes in seropositive individuals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07-23

AUTHORS

Bruce D. Walker, Sekhar Chakrabarti, Bernard Moss, Timothy J. Paradis, Theresa Flynn, Amy G. Durno, Richard S. Blumberg, Joan C. Kaplan, Martin S. Hirsch, Robert T. Schooley

ABSTRACT

Virus-specific cytotoxic T lymphocytes (CTL) which kill virus-infected cells are thought to be a major host defence against viral infections1–11. Here we report the existence of human immunodeficiency virus (HlV)-specific CTL in persons infected with this virus, the aetiological agent of AIDS (acquired immunodeficiency syndrome). Recombinant HIV-vaccinia viruses were used to express HIV antigens in B-cell lines established from subjects seropositive for HIV and seronegative controls. Circulating lymphocytes capable of killing HIV env-expressing autologous B cells were detected in eight of eight seropositive subjects; in addition, at least three seropositive subjects demonstrated gag-specific cytotoxic responses. No HIV-specific cytotoxicity was observed in seronegative subjects. Selective inhibition of the env-specific cytotoxicity by a CD3-specific monoclonal antibody indicates that the effectors are T cells. This demonstration of a cytotoxic T-cell immune response to HIV in infected individuals should prove useful in investigating the immunopathogenesis of HIV infection further and in evaluating AIDS vaccine strategies. More... »

PAGES

345-348

Journal

TITLE

Nature

ISSUE

6128

VOLUME

328

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/328345a0

    DOI

    http://dx.doi.org/10.1038/328345a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022500911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3496541


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