Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-07

AUTHORS

Peter R. Schofield, Mark G. Darlison, Norihisa Fujita, David R. Burt, F. Anne Stephenson, Henry Rodriguez, Lucy M. Rhee, J. Ramachandran, Vincenzina Reale, Thora A. Glencorse, Peter H. Seeburg, Eric A. Barnard

ABSTRACT

Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor. More... »

PAGES

221-227

Journal

TITLE

Nature

ISSUE

6127

VOLUME

328

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/328221a0

    DOI

    http://dx.doi.org/10.1038/328221a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046436325

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3037384


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