The X-linked chronic granulomatous disease gene codes for the β-chain of cytochrome b −245 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-06

AUTHORS

Carmel Teahan, Peter Rowe, Peter Parker, Nick Totty, Anthony W. Segal

ABSTRACT

Chronic granulomatous disease (CGD) is a rare inherited disorder associated with a profound predisposition to infection due to the lack of a microbicidal oxidase system in the phagocytes of these patients. This syndrome is most commonly inherited through a defect on the X chromosome and the only clearly defined component of the oxidase system, the very unusual cytochrome b (b-245), has been shown to be missing from the cells of these patients. This cytochrome is a heterodimer composed of an alpha-chain of relative molecular mass (Mr) 23,000 (23K) and a 76-92K beta-chain; neither are detectable in neutrophils from X-linked CGD subjects. The defective X-CGD gene has recently been cloned by 'reverse genetics' but the protein predicted from the proposed complementary DNA sequence was not identified. We have purified the beta-chain of the cytochrome and sequenced 43 amino acids from the N terminus. Almost complete homology was obtained between this sequence and that of the complementary nucleotides 19-147 of the sequence of the X-CGD gene, originally designated as a non-coding region. More... »

PAGES

720-721

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/327720a0

DOI

http://dx.doi.org/10.1038/327720a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1056438793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3600769


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