Detection of high incidence of K-ras oncogenes during human colon tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-05

AUTHORS

Kathleen Forrester, Concepcion Almoguera, Kyuhyung Han, William E. Grizzle, Manuel Perucho

ABSTRACT

RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained. More... »

PAGES

298-303

Journal

TITLE

Nature

ISSUE

6120

VOLUME

327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/327298a0

DOI

http://dx.doi.org/10.1038/327298a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026973030

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2438556


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