Detection of high incidence of K-ras oncogenes during human colon tumorigenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-05

AUTHORS

Kathleen Forrester, Concepcion Almoguera, Kyuhyung Han, William E. Grizzle, Manuel Perucho

ABSTRACT

RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained. More... »

PAGES

298-303

Journal

TITLE

Nature

ISSUE

6120

VOLUME

327

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/327298a0

DOI

http://dx.doi.org/10.1038/327298a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026973030

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2438556


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Codon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleic Acid Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Complementary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonuclease, Pancreatic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forrester", 
        "givenName": "Kathleen", 
        "id": "sg:person.0604002745.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604002745.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almoguera", 
        "givenName": "Concepcion", 
        "id": "sg:person.01341655007.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341655007.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Columbia University, 10027, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA", 
            "Department of Biological Sciences, Columbia University, 10027, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Kyuhyung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grizzle", 
        "givenName": "William E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perucho", 
        "givenName": "Manuel", 
        "id": "sg:person.01000314671.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314671.43"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1987-05", 
    "datePublishedReg": "1987-05-01", 
    "description": "RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/327298a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6120", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "327"
      }
    ], 
    "keywords": [
      "high incidence", 
      "human colon tumorigenesis", 
      "ras mutational activation", 
      "degree of invasiveness", 
      "human colon tumors", 
      "colon tumors", 
      "colon tumorigenesis", 
      "premalignant tissue", 
      "primary human colon tumors", 
      "tumors", 
      "mutational activation", 
      "incidence", 
      "ras gene", 
      "ras oncogene", 
      "mutant oncogenes", 
      "oncogene", 
      "apparent correlation", 
      "cleavage analysis", 
      "invasiveness", 
      "tumorigenesis", 
      "tissue", 
      "activation", 
      "position 12", 
      "mutations", 
      "evidence", 
      "genes", 
      "correlation", 
      "presence", 
      "degree", 
      "detection", 
      "analysis", 
      "mismatch cleavage analysis"
    ], 
    "name": "Detection of high incidence of K-ras oncogenes during human colon tumorigenesis", 
    "pagination": "298-303", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026973030"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/327298a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2438556"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/327298a0", 
      "https://app.dimensions.ai/details/publication/pub.1026973030"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T17:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_209.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/327298a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/327298a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/327298a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/327298a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/327298a0'


 

This table displays all metadata directly associated to this object as RDF triples.

188 TRIPLES      21 PREDICATES      75 URIs      67 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/327298a0 schema:about N03348397dca547d394f1557b41502b9a
2 N16cccc6545804c0f933e9f32239a9480
3 N1b08c19b01b747efad117fa87e7b8eac
4 N1ca864ada8b44ca996a81bf8f2c34712
5 N53a9a218d08543e78e8abb7a4ce718c1
6 N5e4ec2db5e8a44b8bfe0a3ed8a3addbd
7 N6783ca144a954ba08a9c96c9c198173a
8 N8d7dc454fe70448d96419a68f3690fbf
9 Na4455ae668294111aefa603e77672380
10 Na62b5ed3f40a4b19a0b5b83d577ed250
11 Nb1878dbe6166452485104e434cf411c2
12 Nc5e75aa741e242b9ab53402ce37c9481
13 Nd2b7d70991384b00b457d5dbdea82190
14 Ne36ce682c787496691b827bf8aaecd6d
15 Ne5239fd6505c456c98f6caa8670c8232
16 Ne88c74d929be40e080ca74e67a7e8f9d
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N406b61a7b52444258460526ad7e410a6
20 schema:datePublished 1987-05
21 schema:datePublishedReg 1987-05-01
22 schema:description RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N931de4afd24a4d33a2a80504d9d27ec4
27 Nea3567e7c7d34eff965bb969529e9f59
28 sg:journal.1018957
29 schema:keywords activation
30 analysis
31 apparent correlation
32 cleavage analysis
33 colon tumorigenesis
34 colon tumors
35 correlation
36 degree
37 degree of invasiveness
38 detection
39 evidence
40 genes
41 high incidence
42 human colon tumorigenesis
43 human colon tumors
44 incidence
45 invasiveness
46 mismatch cleavage analysis
47 mutant oncogenes
48 mutational activation
49 mutations
50 oncogene
51 position 12
52 premalignant tissue
53 presence
54 primary human colon tumors
55 ras gene
56 ras mutational activation
57 ras oncogene
58 tissue
59 tumorigenesis
60 tumors
61 schema:name Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
62 schema:pagination 298-303
63 schema:productId N3030c4f4db4e4eafb02861222832214a
64 Nb98e579205b442ad8780be9040af2597
65 Nd156e5daf66444069db085e094ed11c5
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026973030
67 https://doi.org/10.1038/327298a0
68 schema:sdDatePublished 2021-11-01T17:58
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N11f7444f4ff24f4f980f293c1dc6d611
71 schema:url https://doi.org/10.1038/327298a0
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N03348397dca547d394f1557b41502b9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Adenocarcinoma
77 rdf:type schema:DefinedTerm
78 N11f7444f4ff24f4f980f293c1dc6d611 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N16cccc6545804c0f933e9f32239a9480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Ribonuclease, Pancreatic
82 rdf:type schema:DefinedTerm
83 N1b08c19b01b747efad117fa87e7b8eac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Aged, 80 and over
85 rdf:type schema:DefinedTerm
86 N1ca864ada8b44ca996a81bf8f2c34712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Middle Aged
88 rdf:type schema:DefinedTerm
89 N3030c4f4db4e4eafb02861222832214a schema:name doi
90 schema:value 10.1038/327298a0
91 rdf:type schema:PropertyValue
92 N406b61a7b52444258460526ad7e410a6 rdf:first sg:person.0604002745.41
93 rdf:rest Na25d0e2040a24ecd9d4f08056d8f2b9b
94 N4d7526efe10e492a975b96a446cfbdf9 schema:affiliation grid-institutes:grid.21729.3f
95 schema:familyName Han
96 schema:givenName Kyuhyung
97 rdf:type schema:Person
98 N53a9a218d08543e78e8abb7a4ce718c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Oncogenes
100 rdf:type schema:DefinedTerm
101 N5e4ec2db5e8a44b8bfe0a3ed8a3addbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mutation
103 rdf:type schema:DefinedTerm
104 N6783ca144a954ba08a9c96c9c198173a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Nucleic Acid Hybridization
106 rdf:type schema:DefinedTerm
107 N8d27e70a4dfa478899a3a08892718977 rdf:first N4d7526efe10e492a975b96a446cfbdf9
108 rdf:rest Nc6de248aa1d7452d8ebfa929eab8d5d9
109 N8d7dc454fe70448d96419a68f3690fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aged
111 rdf:type schema:DefinedTerm
112 N90bc16c0e82e47b7893471b48f338ea0 schema:affiliation grid-institutes:grid.36425.36
113 schema:familyName Grizzle
114 schema:givenName William E.
115 rdf:type schema:Person
116 N931de4afd24a4d33a2a80504d9d27ec4 schema:issueNumber 6120
117 rdf:type schema:PublicationIssue
118 Na25d0e2040a24ecd9d4f08056d8f2b9b rdf:first sg:person.01341655007.39
119 rdf:rest N8d27e70a4dfa478899a3a08892718977
120 Na4455ae668294111aefa603e77672380 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 Na62b5ed3f40a4b19a0b5b83d577ed250 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Colonic Neoplasms
125 rdf:type schema:DefinedTerm
126 Nb1878dbe6166452485104e434cf411c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Female
128 rdf:type schema:DefinedTerm
129 Nb98e579205b442ad8780be9040af2597 schema:name pubmed_id
130 schema:value 2438556
131 rdf:type schema:PropertyValue
132 Nc5e75aa741e242b9ab53402ce37c9481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name RNA
134 rdf:type schema:DefinedTerm
135 Nc6de248aa1d7452d8ebfa929eab8d5d9 rdf:first N90bc16c0e82e47b7893471b48f338ea0
136 rdf:rest Nde32c242c2d74748a87df2c24f6ae551
137 Nd156e5daf66444069db085e094ed11c5 schema:name dimensions_id
138 schema:value pub.1026973030
139 rdf:type schema:PropertyValue
140 Nd2b7d70991384b00b457d5dbdea82190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adenoma
142 rdf:type schema:DefinedTerm
143 Nde32c242c2d74748a87df2c24f6ae551 rdf:first sg:person.01000314671.43
144 rdf:rest rdf:nil
145 Ne36ce682c787496691b827bf8aaecd6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Codon
147 rdf:type schema:DefinedTerm
148 Ne5239fd6505c456c98f6caa8670c8232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Male
150 rdf:type schema:DefinedTerm
151 Ne88c74d929be40e080ca74e67a7e8f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name RNA, Complementary
153 rdf:type schema:DefinedTerm
154 Nea3567e7c7d34eff965bb969529e9f59 schema:volumeNumber 327
155 rdf:type schema:PublicationVolume
156 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
157 schema:name Biological Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biochemistry and Cell Biology
161 rdf:type schema:DefinedTerm
162 sg:journal.1018957 schema:issn 0028-0836
163 1476-4687
164 schema:name Nature
165 schema:publisher Springer Nature
166 rdf:type schema:Periodical
167 sg:person.01000314671.43 schema:affiliation grid-institutes:grid.36425.36
168 schema:familyName Perucho
169 schema:givenName Manuel
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314671.43
171 rdf:type schema:Person
172 sg:person.01341655007.39 schema:affiliation grid-institutes:grid.36425.36
173 schema:familyName Almoguera
174 schema:givenName Concepcion
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341655007.39
176 rdf:type schema:Person
177 sg:person.0604002745.41 schema:affiliation grid-institutes:grid.36425.36
178 schema:familyName Forrester
179 schema:givenName Kathleen
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604002745.41
181 rdf:type schema:Person
182 grid-institutes:grid.21729.3f schema:alternateName Department of Biological Sciences, Columbia University, 10027, New York, New York, USA
183 schema:name Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA
184 Department of Biological Sciences, Columbia University, 10027, New York, New York, USA
185 rdf:type schema:Organization
186 grid-institutes:grid.36425.36 schema:alternateName Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA
187 schema:name Department of Biochemistry, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA
188 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...