Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-05

AUTHORS

Y. Kuchino, F. Mori, H. Kasai, H. Inoue, S. Iwai, K. Miura, E. Ohtsuka, S. Nishimura

ABSTRACT

It has been shown previously that deoxyguanosine residues in DNA are hydroxylated at the C-8 position both in vitro and in vivo to produce 8-hydroxydeoxyguanosine (8-OH-dG) by various agents that produce oxygen radicals such as reducing reagents-O2, metal ions-O2, poryphenol-H2O2-Fe3+, asbestos-H2O2 or ionizing radi-ation1–5. These agents are mostly either mutagenic or carcinogenic; therefore, the formation of 8-OH-dG can also be considered a likely cause of mutation or carcinogenesis by oxygen radicals. It is of interest to know whether the 8-OH-dG residue in DNA is misread during DNA replication. To answer this question, we have examined the effect of the 8-OH-dG residue in DNA on the fidelity of DNA replication using a DNA synthesis system in vitro with Escherichia coli DNA polymerase I (Klenow fragment). The syn-thetic oligodeoxynucleotides, with or without an 8-OH-dG residue in a specified position, were chemically synthesized and used as templates for DNA synthesis under the conditions of the dideoxy chain termination sequencing method. Surprisingly, in addition to misreading of the 8-OH-dG residue itself, pyrimidines next to the 8-OH-dG residue (G has not yet been tested) were also misread. More... »

PAGES

77-79

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/327077a0

DOI

http://dx.doi.org/10.1038/327077a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022102715

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3574469


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