Transfection of the CD8 gene enhances T-cell recognition View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-04-01

AUTHORS

Zlatko Dembić, Werner Haas, Rose Zamoyska, Jane Parnes, Michael Steinmetz, Harald von Boehmer

ABSTRACT

Antibodies against CD8 or CD4 antigens can prevent T-cell functions induced by T-cell targets1–3. As CD8 or CD4 antibodies can also initiate negative signals in T cells in the absence of appropriate targets4–6 it is not clear whether CD8 and CD4 molecules are directly involved in the interaction of T cells with their targets. In previous experiments we have introduced the T-cell receptor α-and β-chain genes from a CD8-positive cytolytic T cell specific for the antigen fluorescein (FL) and the H–2Dd molecule of the major histocompatibility complex (MHC) into a CD8-negative recipient cell. The CD8-positive donor cell lysed both FL-conjugated fibroblasts and lymphoblasts, which express relatively high and low amounts of H–2Dd molecules, respectively. In contrast the CDS-negative transfectant lysed FL-conjugated fibroblasts only7. Here we show that recognition of FL-conjugated lymphoblasts by the transfectant is enhanced by supertransfecting it with the CD8 gene. More... »

PAGES

510-511

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/326510a0

DOI

http://dx.doi.org/10.1038/326510a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021077062

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3031507


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