Modulation of c-"os gene transcription by negative and positive cellular factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-04-01

AUTHORS

Paolo Sassone-Corsi, Inder M. Verma

ABSTRACT

Regulation of transcription in eukaryotes is mediated by the specific interaction between cellular factors and promoter sequences1. Cis-acting DNA sequences, frequently located upstream of the TATA box, have been implicated in modulating the expression of many genes2. We are interested in the transcriptional regulation of proto-oncogenes because they may have a pivotal function in cell growth and differentiation3,4. Expression of the proto-oncogene c-fos is induced in response to a variety of growth factors and differentiation-specific agents4. The viral cognate of the c-fos gene is the resident transforming gene of FBJ-murine osteosarcoma virus which causes bone tumours in vivo and cellular transformation in vitro5,6. We report here that transcription of the human c-fos gene is modulated by negatively and positively acting cellular factors. More... »

PAGES

507-510

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/326507a0

DOI

http://dx.doi.org/10.1038/326507a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029759423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3561489


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Exons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sassone-Corsi", 
        "givenName": "Paolo", 
        "id": "sg:person.0577172601.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577172601.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verma", 
        "givenName": "Inder M.", 
        "id": "sg:person.0711723174.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711723174.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/313458a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002928805", 
          "https://doi.org/10.1038/313458a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-69677-0_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046339493", 
          "https://doi.org/10.1007/978-3-642-69677-0_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/312608a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004572347", 
          "https://doi.org/10.1038/312608a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1987-04-01", 
    "datePublishedReg": "1987-04-01", 
    "description": "Regulation of transcription in eukaryotes is mediated by the specific interaction between cellular factors and promoter sequences1. Cis-acting DNA sequences, frequently located upstream of the TATA box, have been implicated in modulating the expression of many genes2. We are interested in the transcriptional regulation of proto-oncogenes because they may have a pivotal function in cell growth and differentiation3,4. Expression of the proto-oncogene c-fos is induced in response to a variety of growth factors and differentiation-specific agents4. The viral cognate of the c-fos gene is the resident transforming gene of FBJ-murine osteosarcoma virus which causes bone tumours in vivo and cellular transformation in vitro5,6. We report here that transcription of the human c-fos gene is modulated by negatively and positively acting cellular factors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/326507a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6112", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "326"
      }
    ], 
    "keywords": [
      "cellular factors", 
      "FBJ-murine osteosarcoma virus", 
      "cis-acting DNA sequences", 
      "fos gene", 
      "regulation of transcription", 
      "proto-oncogene c", 
      "transcriptional regulation", 
      "DNA sequences", 
      "TATA box", 
      "cellular transformation", 
      "gene transcription", 
      "human c", 
      "pivotal function", 
      "transcription", 
      "cell growth", 
      "genes", 
      "specific interactions", 
      "growth factor", 
      "regulation", 
      "expression", 
      "eukaryotes", 
      "upstream", 
      "sequence", 
      "cognates", 
      "Fos", 
      "vivo", 
      "growth", 
      "factors", 
      "virus", 
      "box", 
      "interaction", 
      "function", 
      "modulation", 
      "variety", 
      "response", 
      "transformation", 
      "bone tumors", 
      "tumors", 
      "promoter sequences1", 
      "sequences1", 
      "genes2", 
      "differentiation-specific agents4", 
      "agents4", 
      "viral cognate", 
      "osteosarcoma virus", 
      "c-\"os gene transcription", 
      "positive cellular factors"
    ], 
    "name": "Modulation of c-\"os gene transcription by negative and positive cellular factors", 
    "pagination": "507-510", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029759423"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/326507a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "3561489"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/326507a0", 
      "https://app.dimensions.ai/details/publication/pub.1029759423"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_206.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/326507a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/326507a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/326507a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/326507a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/326507a0'


 

This table displays all metadata directly associated to this object as RDF triples.

168 TRIPLES      22 PREDICATES      86 URIs      75 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/326507a0 schema:about N18c7fc9aca334ea7b62c3a9a1e901c32
2 N37f4a5ed3bb5488eb2bac0d575842349
3 N4e32d87a69974aaabc8bb8495fa5a04a
4 N6f3f995aa9304c5fa51901e86affc93e
5 N7bb04debc05340c595d5bf07d2b91a93
6 N7e873f1e40ca42a6a9795e8c21c6f4e0
7 Ne31c18a431f64962be199bf86849a524
8 Necc6133f9df7460eade7e06a7f46c399
9 Nf14eed8710c54fa498c525f4b685f0b9
10 Nf2b67b7b2b9448e7963e7c60b60a4db4
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N7e36c5e2f9bc470d81b0fccf3b601ade
14 schema:citation sg:pub.10.1007/978-3-642-69677-0_4
15 sg:pub.10.1038/312608a0
16 sg:pub.10.1038/313458a0
17 schema:datePublished 1987-04-01
18 schema:datePublishedReg 1987-04-01
19 schema:description Regulation of transcription in eukaryotes is mediated by the specific interaction between cellular factors and promoter sequences1. Cis-acting DNA sequences, frequently located upstream of the TATA box, have been implicated in modulating the expression of many genes2. We are interested in the transcriptional regulation of proto-oncogenes because they may have a pivotal function in cell growth and differentiation3,4. Expression of the proto-oncogene c-fos is induced in response to a variety of growth factors and differentiation-specific agents4. The viral cognate of the c-fos gene is the resident transforming gene of FBJ-murine osteosarcoma virus which causes bone tumours in vivo and cellular transformation in vitro5,6. We report here that transcription of the human c-fos gene is modulated by negatively and positively acting cellular factors.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf Nbb8f9ca5f66240bb80a6c0874a4f02a8
24 Nc7dda9c162934a928a817d17cb29cce8
25 sg:journal.1018957
26 schema:keywords DNA sequences
27 FBJ-murine osteosarcoma virus
28 Fos
29 TATA box
30 agents4
31 bone tumors
32 box
33 c-"os gene transcription
34 cell growth
35 cellular factors
36 cellular transformation
37 cis-acting DNA sequences
38 cognates
39 differentiation-specific agents4
40 eukaryotes
41 expression
42 factors
43 fos gene
44 function
45 gene transcription
46 genes
47 genes2
48 growth
49 growth factor
50 human c
51 interaction
52 modulation
53 osteosarcoma virus
54 pivotal function
55 positive cellular factors
56 promoter sequences1
57 proto-oncogene c
58 regulation
59 regulation of transcription
60 response
61 sequence
62 sequences1
63 specific interactions
64 transcription
65 transcriptional regulation
66 transformation
67 tumors
68 upstream
69 variety
70 viral cognate
71 virus
72 vivo
73 schema:name Modulation of c-"os gene transcription by negative and positive cellular factors
74 schema:pagination 507-510
75 schema:productId N02b2e1d95e914eaa8daf8bea037372c9
76 N28187face5bc403db3f810d5c0f8a903
77 N46227b03771c4a1f9d3dd9e73c2d5768
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029759423
79 https://doi.org/10.1038/326507a0
80 schema:sdDatePublished 2022-01-01T18:04
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N42cc9b42f8354f21bfc9c1ddadc5c6dc
83 schema:url https://doi.org/10.1038/326507a0
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N02b2e1d95e914eaa8daf8bea037372c9 schema:name pubmed_id
88 schema:value 3561489
89 rdf:type schema:PropertyValue
90 N18c7fc9aca334ea7b62c3a9a1e901c32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Cell Transformation, Neoplastic
92 rdf:type schema:DefinedTerm
93 N28187face5bc403db3f810d5c0f8a903 schema:name dimensions_id
94 schema:value pub.1029759423
95 rdf:type schema:PropertyValue
96 N37f4a5ed3bb5488eb2bac0d575842349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Plasmids
98 rdf:type schema:DefinedTerm
99 N42cc9b42f8354f21bfc9c1ddadc5c6dc schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N46227b03771c4a1f9d3dd9e73c2d5768 schema:name doi
102 schema:value 10.1038/326507a0
103 rdf:type schema:PropertyValue
104 N4e32d87a69974aaabc8bb8495fa5a04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cells, Cultured
106 rdf:type schema:DefinedTerm
107 N6f3f995aa9304c5fa51901e86affc93e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Proto-Oncogenes
109 rdf:type schema:DefinedTerm
110 N71e3fcd327f34acc92d255f77d168c12 rdf:first sg:person.0711723174.90
111 rdf:rest rdf:nil
112 N7bb04debc05340c595d5bf07d2b91a93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Exons
114 rdf:type schema:DefinedTerm
115 N7e36c5e2f9bc470d81b0fccf3b601ade rdf:first sg:person.0577172601.52
116 rdf:rest N71e3fcd327f34acc92d255f77d168c12
117 N7e873f1e40ca42a6a9795e8c21c6f4e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Transcription, Genetic
119 rdf:type schema:DefinedTerm
120 Nbb8f9ca5f66240bb80a6c0874a4f02a8 schema:issueNumber 6112
121 rdf:type schema:PublicationIssue
122 Nc7dda9c162934a928a817d17cb29cce8 schema:volumeNumber 326
123 rdf:type schema:PublicationVolume
124 Ne31c18a431f64962be199bf86849a524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mice
126 rdf:type schema:DefinedTerm
127 Necc6133f9df7460eade7e06a7f46c399 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Genes, Regulator
129 rdf:type schema:DefinedTerm
130 Nf14eed8710c54fa498c525f4b685f0b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 Nf2b67b7b2b9448e7963e7c60b60a4db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Promoter Regions, Genetic
135 rdf:type schema:DefinedTerm
136 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
137 schema:name Biological Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
140 schema:name Genetics
141 rdf:type schema:DefinedTerm
142 sg:journal.1018957 schema:issn 0028-0836
143 1476-4687
144 schema:name Nature
145 schema:publisher Springer Nature
146 rdf:type schema:Periodical
147 sg:person.0577172601.52 schema:affiliation grid-institutes:grid.250671.7
148 schema:familyName Sassone-Corsi
149 schema:givenName Paolo
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577172601.52
151 rdf:type schema:Person
152 sg:person.0711723174.90 schema:affiliation grid-institutes:grid.250671.7
153 schema:familyName Verma
154 schema:givenName Inder M.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711723174.90
156 rdf:type schema:Person
157 sg:pub.10.1007/978-3-642-69677-0_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046339493
158 https://doi.org/10.1007/978-3-642-69677-0_4
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/312608a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004572347
161 https://doi.org/10.1038/312608a0
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/313458a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002928805
164 https://doi.org/10.1038/313458a0
165 rdf:type schema:CreativeWork
166 grid-institutes:grid.250671.7 schema:alternateName Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA
167 schema:name Molecular Biology and Virology Laboratory, The Salk Institute, Box 85800, 92138, San Diego, California, USA
168 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...