Possible role for fatty acyl-coenzyme A in intracellular protein transport View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-03

AUTHORS

Benjamin S. Glick, James E. Rothman

ABSTRACT

The transport of proteins between subcellular compartments is a vectorial, energy-requiring process mediated by the budding and fusion of a series of vesicular carriers. As yet, nothing is known of the chemical reactions that underlie these events, or how or in exactly what forms energy is used to sustain such movements. Here we report that fatty acyl-CoA acts as cofactor to a Golgi-associated protein factor (termed NSF) that is required for transport between cisternae of the Golgi stack in a cell-free system. This previously unsuspected connection may offer a link between the complex process of protein transport and a single, well-defined type of chemical reaction. We suggest that an ATP-dependent cycle of fatty acylation and deacylation may play an important role in driving rounds of vectorial protein transport. More... »

PAGES

309-312

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/326309a0

DOI

http://dx.doi.org/10.1038/326309a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002415762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3821906


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