HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-03

AUTHORS

Ricardo Pujol–Borrell, Ian Todd, Mala Doshi, Gian Franco Bottazzo, Robert Sutton, Derek Gary, Gunther R. Adolf, Marc Feldmann

ABSTRACT

HLA class II molecules are surface glycoproteins which are essential in the initiation of immune responses. It has been postulated that induction of class II in epithelial cells such as endocrine cells, which are normally class II negative, may result in autoimmunity. In type I diabetes, islet beta cells, the target of the autoimmune process, selectively express class II antigens. But in contrast to most other cell types, islet beta cells are not stimulated to express class II by interferon-gamma (IFN-gamma) and thus the conditions under which this induction occurs have been particularly elusive. The cytotoxins tumour necrosis factor (TNF) and lymphotoxin (LT) synergize with IFN-gamma in a number of activities. We report here that IFN-gamma in combination with either TNF or LT induces islet cell class II expression. This finding has important implications for the pathogenesis of type I diabetes and the understanding of the differential control of class II expression. More... »

PAGES

304-306

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/326304a0

DOI

http://dx.doi.org/10.1038/326304a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006495811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3102976


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