Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-01

AUTHORS

Lothar Schweigerer, Gera Neufeld, Jeff Friedman, Judith A. Abraham, John C. Fiddes, Denis Gospodarowicz

ABSTRACT

Angiogenesis, the formation of new capillaries, which is observed in embryonic and injured tissue and is particularly prominent in the vicinity of solid tumours, involves the migration and proliferation of capillary endothelial cells. It is probably triggered by agents, such as basic fibroblast growth factor (bFGF), thought to be released from tissues adjacent to proliferating capillaries. As well as being a potent inducer of cell division in capillary endothelial cells in vitro, bFGF can act as an angiogenic agent in vivo. It is present in a wide variety of richly vascularized tissues including brain, pituitary, retina, adrenal gland, kidney, corpus luteum, placenta and various tumours. So far, however, the normal bFGF-producing cell species in these tissues have not been identified. We report here that capillary endothelial cells express the bFGF gene, that they produce and release bFGF and that bFGF derived from them can stimulate the proliferation of capillary endothelial cells. We conclude that bFGF can act as a self-stimulating growth factor for capillary endothelial cells, and that it is possible that the formation of new capillaries is induced by capillary endothelial cells themselves. More... »

PAGES

257-259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/325257a0

DOI

http://dx.doi.org/10.1038/325257a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020191001

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2433585


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