Astrocytes induce blood–brain barrier properties in endothelial cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1987-01

AUTHORS

Robert C. Janzer, Martin C. Raff

ABSTRACT

The highly impermeable tight junctions between endothelial cells forming the capillaries and venules in the central nervous system (CNS) of higher vertebrates are thought to be responsible for the blood-brain barrier1,2 that impedes the passive diffusion of solutes from the blood into the extracellular space of the CNS3–6. The ability of CNS endothelial cells to form a blood-brain barrier is not intrinsic to these cells but instead is induced by the CNS environment: Stewart and Wiley7 demonstrated that when avascular tissue from 3-day-old quail brain is transplanted into the coelomic cavity of chick embryos, the chick endothelial cells that vascularize the quail brain grafts form a competent blood–brain barrier; on the other hand, when avascular embryonic quail coelomic grafts are transplanted into embryonic chick brain, the chick endothelial cells that invade the mesenchymal tissue grafts form leaky capillaries and venules. It is, however, not known which cells in the CNS are responsible for inducing endothelial cells to form the tight junctions characteristic of the blood–brain barrier. Astrocytes are the most likely candidates since their processes form endfeet that collectively surround CNS microvessels8,9. In this report we provide direct evidence that astrocytes are capable of inducing blood–brain barrier properties in non-neural endothelial cells in vivo. More... »

PAGES

253-257

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/325253a0

DOI

http://dx.doi.org/10.1038/325253a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020634435

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3543687


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