Differential and stage-related expression in embryonic tissues of a new human homoeobox gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-12

AUTHORS

Fulvio Mavilio, Antonio Simeone, Adele Giampaolo, Antonio Faiella, Vincenzo Zappavigna, Dario Acampora, Giancarlo Poiana, Giovanni Russo, Cesare Peschle, Edoardo Boncinelli

ABSTRACT

The homoeobox is a 183 base-pair (bp) DNA sequence conserved in several Drosophila genes controlling segmentation and segment identity. Homoeobox sequences have been detected in the genome of species ranging from insects and anellids to vertebrates and homoeobox containing genes have been cloned from Xenopus, mouse and man. We recently isolated human homoeobox containing complementary DNA clones, that represent transcripts from four different human genes. One clone (HHO.c10) is selectively expressed in a 2.1 kilobase (kb) polyadenylated transcript in the spinal cord of human embryos and fetuses 5-10 weeks after fertilization. We report the characterization of a second cDNA clone, termed HHO.c13, that represents a new homoeobox gene. This clone encodes a protein of 255 amino-acid residues, which includes a pentapeptide, upstream of the homoeo domain, conserved in other Drosophila, Xenopus, murine and human homoeobox genes. By Northern analysis HHO.c13 detects multiple embryonic transcripts, which are differentially expressed in spinal cord, brain, backbone rudiments, limb buds and heart in 5-9-week-old human embryos and fetuses, in a striking organ- and stage-specific pattern. These observations suggest that in early mammalian development homoeobox genes may exert a wide spectrum of control functions in a variety of organs and body parts, in addition to the spinal cord. More... »

PAGES

664-668

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/324664a0

DOI

http://dx.doi.org/10.1038/324664a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044308217

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2879245


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