Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-12

AUTHORS

M. Marin-Grez, J. T. Fleming, M. Steinhausen

ABSTRACT

Atrial natriuretic peptide (ANP) can be extracted from rat hearts, and is found to increase fluid excretion by the kidneys when injected into test animals1. The mechanism of ANP action is still unclear. ANP may reduce sodium reabsorption in the renal tubules, but it is also known that it increases the rate of glomerular filtration in the kidney, and relaxes preparations of smooth muscle, including one made from arteries that supply the kidney2,3. To clarify its mode of action, we have studied directly the effects of semi-purified and synthetic ANP on blood vessels in the kidney of anaesthetized rats. We found that ANP causes a vasodilatation of the blood vessels which supply the glomeruli and a vasoconstriction of the arterioles which drain them. This substantiates the finding that increased filtration pressure participates in the natriuretic response4. More... »

PAGES

473-476

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/324473a0

DOI

http://dx.doi.org/10.1038/324473a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020188762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2946962


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Natriuretic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Circulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasoconstriction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasodilation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marin-Grez", 
        "givenName": "M.", 
        "id": "sg:person.055554560.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055554560.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fleming", 
        "givenName": "J. T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Physiologisches Institut der Ludwigs-Maximilian Universit\u00e4t, M\u00fcnchen and I. Physiologisches Institut der Universit\u00e4t, Heidelberg, FRG"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinhausen", 
        "givenName": "M.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/314264a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005838145", 
          "https://doi.org/10.1038/314264a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309717a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026755809", 
          "https://doi.org/10.1038/309717a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00586690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042453515", 
          "https://doi.org/10.1007/bf00586690"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1986-12", 
    "datePublishedReg": "1986-12-01", 
    "description": "Atrial natriuretic peptide (ANP) can be extracted from rat hearts, and is found to increase fluid excretion by the kidneys when injected into test animals1. The mechanism of ANP action is still unclear. ANP may reduce sodium reabsorption in the renal tubules, but it is also known that it increases the rate of glomerular filtration in the kidney, and relaxes preparations of smooth muscle, including one made from arteries that supply the kidney2,3. To clarify its mode of action, we have studied directly the effects of semi-purified and synthetic ANP on blood vessels in the kidney of anaesthetized rats. We found that ANP causes a vasodilatation of the blood vessels which supply the glomeruli and a vasoconstriction of the arterioles which drain them. This substantiates the finding that increased filtration pressure participates in the natriuretic response4.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/324473a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6096", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "324"
      }
    ], 
    "keywords": [
      "atrial natriuretic peptide", 
      "synthetic atrial natriuretic peptide", 
      "blood vessels", 
      "natriuretic peptide", 
      "sodium reabsorption", 
      "ANP action", 
      "glomerular filtration", 
      "fluid excretion", 
      "smooth muscle", 
      "rat heart", 
      "renal tubules", 
      "rat kidney", 
      "kidney", 
      "mode of action", 
      "vasodilatation", 
      "vasoconstriction", 
      "vessels", 
      "artery", 
      "arterioles", 
      "glomeruli", 
      "rats", 
      "excretion", 
      "reabsorption", 
      "muscle", 
      "tubules", 
      "heart", 
      "action", 
      "findings", 
      "peptides", 
      "participates", 
      "animals1", 
      "rate", 
      "effect", 
      "mechanism", 
      "preparation", 
      "filtration", 
      "mode"
    ], 
    "name": "Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney", 
    "pagination": "473-476", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020188762"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/324473a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2946962"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/324473a0", 
      "https://app.dimensions.ai/details/publication/pub.1020188762"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_180.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/324473a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/324473a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/324473a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/324473a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/324473a0'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      75 URIs      63 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/324473a0 schema:about N01d53d5047ad4527b79fd28f6247fd92
2 N141caa9c7c4e416c9720b39c5faf9b8a
3 N3d284125fad54941b73bdab789e23d78
4 N4700f869f2aa43d49266425300666bcd
5 N5e1af8fc574c4f9b854eeeba93efc96f
6 N7946b4f7af2b421cab8e4ca33a06b70c
7 Nb66406b2613245a78ac4c26fc3cc3a9e
8 Nd57d794c08ed4b1a90acc5a20c17afda
9 anzsrc-for:11
10 anzsrc-for:1103
11 anzsrc-for:1116
12 schema:author N2d0120da19e5468b9d3861999f49b4f5
13 schema:citation sg:pub.10.1007/bf00586690
14 sg:pub.10.1038/309717a0
15 sg:pub.10.1038/314264a0
16 schema:datePublished 1986-12
17 schema:datePublishedReg 1986-12-01
18 schema:description Atrial natriuretic peptide (ANP) can be extracted from rat hearts, and is found to increase fluid excretion by the kidneys when injected into test animals1. The mechanism of ANP action is still unclear. ANP may reduce sodium reabsorption in the renal tubules, but it is also known that it increases the rate of glomerular filtration in the kidney, and relaxes preparations of smooth muscle, including one made from arteries that supply the kidney2,3. To clarify its mode of action, we have studied directly the effects of semi-purified and synthetic ANP on blood vessels in the kidney of anaesthetized rats. We found that ANP causes a vasodilatation of the blood vessels which supply the glomeruli and a vasoconstriction of the arterioles which drain them. This substantiates the finding that increased filtration pressure participates in the natriuretic response4.
19 schema:genre article
20 schema:isAccessibleForFree false
21 schema:isPartOf Nb2ac616f8ce24955852405d3d7b37e8a
22 Nc0b74a71e9bf48b18992eeb434bedd6c
23 sg:journal.1018957
24 schema:keywords ANP action
25 action
26 animals1
27 arterioles
28 artery
29 atrial natriuretic peptide
30 blood vessels
31 effect
32 excretion
33 filtration
34 findings
35 fluid excretion
36 glomerular filtration
37 glomeruli
38 heart
39 kidney
40 mechanism
41 mode
42 mode of action
43 muscle
44 natriuretic peptide
45 participates
46 peptides
47 preparation
48 rat heart
49 rat kidney
50 rate
51 rats
52 reabsorption
53 renal tubules
54 smooth muscle
55 sodium reabsorption
56 synthetic atrial natriuretic peptide
57 tubules
58 vasoconstriction
59 vasodilatation
60 vessels
61 schema:name Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney
62 schema:pagination 473-476
63 schema:productId N719dbe3004854a76b649696f025480de
64 Nacfe72960b924c968d7bedbeae4416bf
65 Nb0fd0399cbab4808b77aa60a82ccb75c
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020188762
67 https://doi.org/10.1038/324473a0
68 schema:sdDatePublished 2022-12-01T06:19
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N2f0d4e7b91324811b39c31c310e3c99f
71 schema:url https://doi.org/10.1038/324473a0
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N01d53d5047ad4527b79fd28f6247fd92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Vasodilation
77 rdf:type schema:DefinedTerm
78 N0ac128ddd4814e068621e7ee1a292644 schema:affiliation grid-institutes:None
79 schema:familyName Fleming
80 schema:givenName J. T.
81 rdf:type schema:Person
82 N141caa9c7c4e416c9720b39c5faf9b8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Kidney Glomerulus
84 rdf:type schema:DefinedTerm
85 N1e8bec4f32804408bbd3d338a64e79c7 rdf:first Ncc3809b35c6d4fcaaa461d9c8efbacac
86 rdf:rest rdf:nil
87 N2d0120da19e5468b9d3861999f49b4f5 rdf:first sg:person.055554560.92
88 rdf:rest Na4116fd58fa3455bae60cbd37f45c72a
89 N2f0d4e7b91324811b39c31c310e3c99f schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N3d284125fad54941b73bdab789e23d78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Kidney
93 rdf:type schema:DefinedTerm
94 N4700f869f2aa43d49266425300666bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Animals
96 rdf:type schema:DefinedTerm
97 N5e1af8fc574c4f9b854eeeba93efc96f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Rats
99 rdf:type schema:DefinedTerm
100 N719dbe3004854a76b649696f025480de schema:name dimensions_id
101 schema:value pub.1020188762
102 rdf:type schema:PropertyValue
103 N7946b4f7af2b421cab8e4ca33a06b70c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Renal Circulation
105 rdf:type schema:DefinedTerm
106 Na4116fd58fa3455bae60cbd37f45c72a rdf:first N0ac128ddd4814e068621e7ee1a292644
107 rdf:rest N1e8bec4f32804408bbd3d338a64e79c7
108 Nacfe72960b924c968d7bedbeae4416bf schema:name doi
109 schema:value 10.1038/324473a0
110 rdf:type schema:PropertyValue
111 Nb0fd0399cbab4808b77aa60a82ccb75c schema:name pubmed_id
112 schema:value 2946962
113 rdf:type schema:PropertyValue
114 Nb2ac616f8ce24955852405d3d7b37e8a schema:volumeNumber 324
115 rdf:type schema:PublicationVolume
116 Nb66406b2613245a78ac4c26fc3cc3a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Vasoconstriction
118 rdf:type schema:DefinedTerm
119 Nc0b74a71e9bf48b18992eeb434bedd6c schema:issueNumber 6096
120 rdf:type schema:PublicationIssue
121 Ncc3809b35c6d4fcaaa461d9c8efbacac schema:affiliation grid-institutes:None
122 schema:familyName Steinhausen
123 schema:givenName M.
124 rdf:type schema:Person
125 Nd57d794c08ed4b1a90acc5a20c17afda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Atrial Natriuretic Factor
127 rdf:type schema:DefinedTerm
128 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
129 schema:name Medical and Health Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
132 schema:name Clinical Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
135 schema:name Medical Physiology
136 rdf:type schema:DefinedTerm
137 sg:journal.1018957 schema:issn 0028-0836
138 1476-4687
139 schema:name Nature
140 schema:publisher Springer Nature
141 rdf:type schema:Periodical
142 sg:person.055554560.92 schema:affiliation grid-institutes:None
143 schema:familyName Marin-Grez
144 schema:givenName M.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055554560.92
146 rdf:type schema:Person
147 sg:pub.10.1007/bf00586690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042453515
148 https://doi.org/10.1007/bf00586690
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/309717a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026755809
151 https://doi.org/10.1038/309717a0
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/314264a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005838145
154 https://doi.org/10.1038/314264a0
155 rdf:type schema:CreativeWork
156 grid-institutes:None schema:alternateName Physiologisches Institut der Ludwigs-Maximilian Universität, München and I. Physiologisches Institut der Universität, Heidelberg, FRG
157 schema:name Physiologisches Institut der Ludwigs-Maximilian Universität, München and I. Physiologisches Institut der Universität, Heidelberg, FRG
158 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...